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A Randomized Comparison between Everolimus-Eluting Stent and Cobalt Chromium Stent in Patients with Acute ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention Using Routine Intravenous Eptifibatide: The X-MAN (Xience vs. Multi-Link Stent in Acute Myocardial Infarction) Trial, A Pilot Study.
MedLine Citation:
PMID:  25075161     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The objective of this study is to determine the efficacy and safety of an everolimus-eluting stent (EES/Xience; Abbott Vascular, Santa Clara, CA) compared with a cobalt chromium stent (CoCr/Multi-Link Vision; Abbott Vascular) in patients with acute ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) with routine administration of eptifibatide infusion. This is a prospective, single center, randomized trial comparing EES (n = 75) and CoCr stent (n = 75) implantation in patients with acute STEMI undergoing primary PCI. Intravenous eptifibatide administration was mandatory by protocol in this pilot study. The primary efficacy endpoint was major adverse cardiac events (MACE) at 30 days, defined as the composite of death, reinfarction, and target vessel revascularization. Secondary safety endpoints were stent thrombosis at 30 days and in-hospital bleeding event. Acute reperfusion parameters were also assessed. One-month MACE rate did not differ between EES and CoCr group (1.3 vs. 1.3%, p = 1.0). No stent thrombosis cases were observed in the EES group. The groups did not differ with respect to in-hospital bleeding events (5 vs. 9%, p = 0.37), achievement of final thrombolysis in myocardial infarction flow 2 or 3 (p = 0.21), achievement of myocardial blush grade 2 or 3 (p = 0.45), creatine kinase-MB level at 8 to 12 hours after stenting (p = 0.29), and left ventricular ejection fraction (p = 0.21). This pilot study demonstrates that after one-month follow-up, the use of EES is as safe and effective as the use of CoCr stents in patients with acute STEMI undergoing primary PCI with routine administration of intravenous eptifibatide.
Authors:
Surya Dharma; Alexander J Wardeh; Sunarya Soerianata; Isman Firdaus; J Wouter Jukema
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The International journal of angiology : official publication of the International College of Angiology, Inc     Volume:  23     ISSN:  1061-1711     ISO Abbreviation:  Int. J. Angiol.     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-07-30     Completed Date:  2014-07-30     Revised Date:  2014-08-01    
Medline Journal Info:
Nlm Unique ID:  9504821     Medline TA:  Int J Angiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  93-100     Citation Subset:  -    
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