| A Randomized Comparison of Pulmonary Vein Isolation With Versus Without Concomitant Renal Artery Denervation in Patients With Refractory Symptomatic Atrial Fibrillation and Resistant Hypertension. | |
| | |
MedLine Citation:
|
PMID: 22958958 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVES: The aim of this prospective randomized study was to assess the impact of renal artery denervation in patients with a history of refractory atrial fibrillation (AF) and drug-resistant hypertension who were referred for pulmonary vein isolation (PVI). BACKGROUND: Hypertension is the most common cardiovascular condition responsible for the development and maintenance of AF. Treating drug-resistant hypertension with renal denervation has been reported to control blood pressure, but any effect on AF is unknown. METHODS: Patients with a history of symptomatic paroxysmal or persistent AF refractory to ≥2 antiarrhythmic drugs and drug-resistant hypertension (systolic blood pressure >160 mm Hg despite triple drug therapy) were eligible for enrolment. Consenting patients were randomized to PVI only or PVI with renal artery denervation. All patients were followed ≥1 year to assess maintenance of sinus rhythm and to monitor changes in blood pressure. RESULTS: Twenty-seven patients were enrolled, and 14 were randomized to PVI only, and 13 were randomized to PVI with renal artery denervation. At the end of the follow-up, significant reductions in systolic (from 181 ± 7 to 156 ± 5, p < 0.001) and diastolic blood pressure (from 97 ± 6 to 87 ± 4, p < 0.001) were observed in patients treated with PVI with renal denervation without significant change in the PVI only group. Nine of the 13 patients (69%) treated with PVI with renal denervation were AF-free at the 12-month post-ablation follow-up examination versus 4 (29%) of the 14 patients in the PVI-only group (p = 0.033). CONCLUSIONS: Renal artery denervation reduces systolic and diastolic blood pressure in patients with drug-resistant hypertension and reduces AF recurrences when combined with PVI. (Percutaneous Renal Denervation and Catheter Ablation of Atrial Fibrillation in Patients With Atrial Fibrillation and Resistant Hypertension; NCT01117025). |
| | |
Authors:
|
Evgeny Pokushalov; Alexander Romanov; Giorgio Corbucci; Sergey Artyomenko; Vera Baranova; Alex Turov; Natalya Shirokova; Alexander Karaskov; Suneet Mittal; Jonathan S Steinberg |
Related Documents
:
|
9577478 - Prolongation and optimization of doppler enhancement with a microbubble us contrast age... 15458088 - An investigation of immersiveness in virtual reality exposure using physiological data. 23499278 - Screening for asymptomatic atrial fibrillation while monitoring the blood pressure at h... 23137508 - Biomarkers in acutely decompensated heart failure with preserved or reduced ejection fr... 18395538 - The effect of different investment techniques on the surface roughness and irregulariti... 7582318 - Rigid external resistances cause effort dependent maximal expiratory and inspiratory fl... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-8-23 |
Journal Detail:
|
Title: Journal of the American College of Cardiology Volume: - ISSN: 1558-3597 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 2012 Aug |
Date Detail:
|
Created Date: 2012-9-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
State Research Institute of Circulation Pathology, Novosibirsk, Russia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: 2-Year Patient-Related Versus Stent-Related Outcomes: The SORT OUT IV (Scandinavian Organization for...
Next Document: Aspiration of tracheoesophageal prosthesis in a laryngectomized patient.