Document Detail


Randomization in clinical trials: conclusions and recommendations.
MedLine Citation:
PMID:  3203526     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The statistical properties of simple (complete) randomization, permuted-block (or simply blocked) randomization, and the urn adaptive biased-coin randomization are summarized. These procedures are contrasted to covariate adaptive procedures such as minimization and to response adaptive procedures such as the play-the-winner rule. General recommendations are offered regarding the use of complete, permuted-block, or urn randomization. In a large double-masked trial, any of these procedures may be acceptable. For a given trial, the relative merits of each procedure should be carefully weighed in relation to the characteristics of the trial. Important considerations are the size of the trial, overall as well as within the smallest subgroup to be employed in a subgroup-specific analysis, whether or not the trial is to be masked, and the resources needed to perform the proper randomization-based permutational analysis.
Authors:
J M Lachin; J P Matts; L J Wei
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Controlled clinical trials     Volume:  9     ISSN:  0197-2456     ISO Abbreviation:  Control Clin Trials     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-02-03     Completed Date:  1989-02-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8006242     Medline TA:  Control Clin Trials     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  365-74     Citation Subset:  IM    
Affiliation:
George Washington University, Department of Statistics/Computer and Information Systems, Rockville, Maryland 20852.
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MeSH Terms
Descriptor/Qualifier:
Clinical Trials as Topic / methods*
Humans
Models, Statistical
Random Allocation*
Research Design*
Grant Support
ID/Acronym/Agency:
N01-DK-2-2206/DK/NIDDK NIH HHS; R01-AM-27769/AM/NIADDK NIH HHS; R01-DK-39826/DK/NIDDK NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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