| Randomised two way crossover comparison of the effects of six weeks propranolol and acebutolol therapy on plasma lipid profiles in patients with hypertension or ischaemic heart disease. | |
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MedLine Citation:
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PMID: 2081608 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of propranolol and acebutolol therapy on serum lipoproteins was studied in thirty patients (mean age 43.9 +/- 8.7 years) with essential hypertension and/or stable myocardial ischaemia. Patients received six weeks therapy with propranolol (80-160 mg per day) and acebutolol (400-800 mg per day) each in random order and were changed over from one to the other beta-blocker after 6 weeks therapy. On propranolol treatment there was no significant effect on total cholesterol and LDL-cholesterol but the concentration of serum triglycerides (94.2 +/- 37.7 to 129.1 +/- 41.2 mg/dl) and VLDL cholesterol (18.9 +/- 7.8 to 26.1 +/- 8.1 mg/dl) significantly increased, concentration of HDL cholesterol (49.5 +/- 9.4 to 42.4 +/- 8.7 mg/dl) significantly decreased (p less than 0.01). Atherogenic index also worsened from 4.17 +/- 0.48 to 5.15 +/- 0.54 (p less than 0.05) on propranolol therapy. Acebutolol therapy, on the other hand, produced no significant change in the concentration of total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol and VLDL cholesterol. |
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Authors:
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S Tyagi; M Bhargava; J Bhattacharya; M Khalilullah |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Indian heart journal Volume: 42 ISSN: 0019-4832 ISO Abbreviation: Indian Heart J Publication Date: 1990 Mar-Apr |
Date Detail:
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Created Date: 1991-05-06 Completed Date: 1991-05-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374675 Medline TA: Indian Heart J Country: INDIA |
Other Details:
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Languages: eng Pagination: 117-9 Citation Subset: IM |
Affiliation:
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Department of Cardiology and Biochemistry, G.B. Pant Hospital, New Delhi. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acebutolol
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administration & dosage*,
therapeutic use Adult Cholesterol / blood Coronary Disease / blood, drug therapy* Drug Administration Schedule Drug Therapy, Combination Female Humans Hypertension / blood, drug therapy* Lipids / blood* Lipoproteins / blood Male Middle Aged Propranolol / administration & dosage*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Lipids; 0/Lipoproteins; 37517-30-9/Acebutolol; 525-66-6/Propranolol; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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