Document Detail

Randomised trial of intravenous infusion of ephedrine or mephentermine for management of hypotension during spinal anaesthesia for Caesarean section.
MedLine Citation:
PMID:  15601269     Owner:  NLM     Status:  MEDLINE    
This study compared the effects of intravenous infusions of ephedrine and mephentermine for maintenance of maternal arterial pressure and neonatal outcome in pregnant women receiving subarachnoid block for lower segment Caesarean section. Sixty patients who developed hypotension following subarachnoid block for Caesarean section were randomly divided into two groups of 30 each to receive an intravenous infusion of ephedrine or mephentermine. Hypotension was defined as a decrease in systolic blood pressure of > or = 20% from the baseline value or an absolute value of <100 mmHg, whichever was higher. The vasopressor infusion was titrated to maintain systolic blood pressure between 'hypotension' and baseline values. Baseline haemodynamic parameters, haemodynamic changes subsequent to the start of vasopressor infusion, duration of hypotension and amount of vasopressor required were statistically similar for both groups. Neonatal APGAR scores and acid-base profiles were also comparable. To conclude, mephentermine can be used as safely and effectively as ephedrine for the management of hypotension during spinal anaesthesia in patients undergoing elective Caesarean section.
A Kansal; M Mohta; A K Sethi; A Tyagi; P Kumar
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia     Volume:  60     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-12-16     Completed Date:  2005-01-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  England    
Other Details:
Languages:  eng     Pagination:  28-34     Citation Subset:  AIM; IM    
Department of Anaesthesiology and Critical care, University College of Medical Sciences, Guru Teg Bahadur Hospital, Delhi 110096, India.
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MeSH Terms
Adrenergic Agents / adverse effects,  therapeutic use
Anesthesia, Obstetrical / adverse effects*
Anesthesia, Spinal / adverse effects*
Apgar Score
Cesarean Section
Double-Blind Method
Ephedrine / adverse effects,  therapeutic use*
Hemodynamics / drug effects
Hypotension / drug therapy*,  etiology
Infusions, Intravenous
Mephentermine / adverse effects,  therapeutic use*
Pregnancy Outcome
Vasoconstrictor Agents / adverse effects,  therapeutic use
Reg. No./Substance:
0/Adrenergic Agents; 0/Vasoconstrictor Agents; 100-92-5/Mephentermine; 299-42-3/Ephedrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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