Document Detail


Randomised trial of interferon alpha2b plus ribavirin for 48 weeks or for 24 weeks versus interferon alpha2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus. International Hepatitis Interventional Therapy Group (IHIT)
MedLine Citation:
PMID:  9807989     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Only 15-20% of patients with chronic hepatitis C achieve a sustained virological response with interferon therapy. The aim of this study was to compare the efficacy and safety of interferon alpha2b in combination with oral ribavirin with interferon alone, for treatment of chronic infection with hepatitis C virus (HCV). METHODS: 832 patients aged 18 years or more with chronic HCV who had not been treated with interferon or ribavirin, were enrolled and randomly allocated one of three regimens: 3 mega units (MU) interferon alpha2b three times a week plus 1000-1200 mg ribavirin per day for 48 weeks; 3 MU interferon alpha2b three times a week plus 1000-1200 mg ribavirin per day for 24 weeks; or 3 MU interferon alpha2b three times a week and placebo for 48 weeks. All patients were assessed for safety, tolerance, and efficacy at the end of weeks 1, 2, 4, 6, and 8, and every 4 weeks during treatment. After treatment was completed patients were followed up on weeks 4, 8, 12, and 24. The primary endpoint was loss of detectable HCV-RNA (serum HCV-RNA <100 copies/mL) at week 24 after treatment. FINDINGS: Sustained virological response at 24 weeks after treatment, was found in 119 (43%) of the 277 patients treated for 48 weeks with the combination regimen, 97 (35%) of the 277 patients treated for 24 weeks with the combination regimen (p=O.055), and 53 (19%) of the 278 patients treated for 48 weeks with interferon alone (p<0.001 vs both combination regimens, intention-to-treat analysis). Logistic regression identified five independent factors significantly associated with response: genotype 2 or 3, viral load less than 2 million copies/mL, age 40 years or less, minimal fibrosis stage, and female sex. Among patients with fewer than three of these factors the odds ratio of sustained response was 2.6 (95% Cl 1.4-4.8; p=0.002) for the 48 week combination regimen compared with 24 weeks of the combination regimen. Discontinuation of therapy for adverse events was more frequent with combination (19%) and monotherapy (13%) given for 48 weeks than combination therapy given for 24 weeks (8%). INTERPRETATION: An interferon alpha2b plus ribavirin combination is more effective than 48 weeks of interferon alpha2b monotherapy and has an acceptable safety profile. Patients with few favourable factors benefit more from extending the duration of combination therapy to 48 weeks.
Authors:
T Poynard; P Marcellin; S S Lee; C Niederau; G S Minuk; G Ideo; V Bain; J Heathcote; S Zeuzem; C Trepo; J Albrecht
Related Documents :
17180529 - Early relapse in multiple sclerosis-associated optic neuritis following the use of inte...
10597779 - A randomized study comparing triple versus double antiretroviral therapy or no treatmen...
17461849 - Concomitant use of gastric acid-reducing agents is frequent among hiv-1-infected patien...
19616339 - Antiviral therapy reduces portal pressure in patients with cirrhosis due to hbeag-negat...
9444929 - Results of the multicenter natural interferon-alpha treatment for chronic hepatitis c: ...
17237999 - Long-term results of interferon alpha monotherapy in patients with hbeag-negative chron...
9285659 - Pilot study and protocol of the canadian trial of atrial fibrillation (ctaf).
4019999 - Incidence and correlates of incontinence in stroke patients.
24121829 - Arthroscopic partial anterior synovectomy of the knee on patients with haemophilia.
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lancet     Volume:  352     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1998-11-20     Completed Date:  1998-11-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1426-32     Citation Subset:  AIM; IM    
Affiliation:
Groupe Hospitalier, Faculté Pitie-Salpêtrière, Université Paris VI, URA CNRS 1484, France. tpoynard@teaser.fr
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Antiviral Agents / administration & dosage,  therapeutic use*
Drug Administration Schedule
Drug Therapy, Combination
Female
Genotype
Hepatitis C, Chronic / drug therapy*,  genetics
Humans
Interferon Alfa-2b / administration & dosage,  therapeutic use*
Male
Middle Aged
RNA, Viral / blood
Ribavirin / administration & dosage,  therapeutic use*
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/RNA, Viral; 36791-04-5/Ribavirin; 99210-65-8/Interferon Alfa-2b
Comments/Corrections
Comment In:
Lancet. 1999 Feb 6;353(9151):499; author reply 500   [PMID:  9989746 ]
Lancet. 1999 Feb 6;353(9151):499-500   [PMID:  9989747 ]
ACP J Club. 1999 May-Jun;130(3):70

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Long-term results of RITA-1 trial: clinical and cost comparisons of coronary angioplasty and coronar...
Next Document:  Positron emission tomographic evidence of toxic effect of MDMA ("Ecstasy") on brain serotonin neuron...