Document Detail

Randomised trial of dopamine compared with hydrocortisone for the treatment of hypotensive very low birthweight infants.
MedLine Citation:
PMID:  9175947     Owner:  NLM     Status:  MEDLINE    
AIM: To compare the efficacy of hydrocortisone with dopamine for the treatment of hypotensive, very low birthweight (VLBW) infants. METHODS: Forty infants were randomly allocated to receive either hydrocortisone (n = 21) or dopamine (n = 19). RESULTS: All 19 infants randomised to dopamine responded; 17 of 21 (81%) did so in the hydrocortisone group. Three of the four non-responders in the hydrocortisone group had clinically significant left to right ductal shunting. The incidence of bronchopulmonary dysplasia, retinopathy of prematurity, intraventricular haemorrhage, necrotising enterocolitis, symptomatic patent ductus arteriosus, hyperglycaemia, sepsis (bacterial or fungal) or survival did not differ between groups. The adrenocorticotrophic hormone (ACTH) stimulated plasma cortisol activity, either before or after treatment, did not differ between the two groups of infants. Although a significant difference in efficacy between dopamine and hydrocortisone was not noted (P = 0.108), there were four treatment failures in the hydrocortisone group, compared with none in the dopamine group. CONCLUSION: Both hydrocortisone and dopamine are effective treatments for hypotension in very low birthweight infants.
D Bourchier; P J Weston
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  76     ISSN:  1359-2998     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-06-26     Completed Date:  1997-06-26     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  F174-8     Citation Subset:  AIM; IM    
Waikato Hospital, Hamilton, New Zealand.
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MeSH Terms
Anti-Inflammatory Agents / therapeutic use*
Dopamine / therapeutic use*
Hydrocortisone / blood,  therapeutic use*
Hypotension / blood,  drug therapy*
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / blood,  drug therapy*
Infant, Very Low Birth Weight*
Reg. No./Substance:
0/Anti-Inflammatory Agents; 50-23-7/Hydrocortisone
Comment In:
Arch Dis Child Fetal Neonatal Ed. 1998 Mar;78(2):F158   [PMID:  9577296 ]

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