| Randomised trial of chemo-endocrine therapy, endocrine therapy, and mastectomy alone in postmenopausal patients with operable breast cancer and axillary node metastasis. | |
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MedLine Citation:
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PMID: 6144974 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adjuvant therapy after total mastectomy and axillary clearance in postmenopausal women with breast cancer and axillary node metastasis was assessed; chemo-endocrine therapy (cyclophosphamide, methotrexate, fluorouracil, prednisone, and tamoxifen; CMFp + T) was compared with endocrine therapy (prednisone and tamoxifen; p + T), and with no adjuvant treatment in 463 patients aged less than or equal to 65 years. Endocrine therapy was compared with no adjuvant therapy in 320 patients aged 66-80 years. At median follow-up of 36 months, disease-free survival was significantly longer in CMFp + T patients than in p + T or control patients; p + T also significantly increased disease-free survival. There were no significant differences in overall survival between the randomised groups. In analyses of patterns of first failure, chemo-endocrine therapy reduced local, regional, and distant relapses, whereas endocrine therapy reduced local and regional recurrences only. |
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Authors:
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Lancet Volume: 1 ISSN: 0140-6736 ISO Abbreviation: Lancet Publication Date: 1984 Jun |
Date Detail:
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Created Date: 1984-07-16 Completed Date: 1984-07-16 Revised Date: 2008-04-25 |
Medline Journal Info:
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Nlm Unique ID: 2985213R Medline TA: Lancet Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1256-60 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antineoplastic Combined Chemotherapy Protocols / therapeutic use* Breast Neoplasms / drug therapy, mortality, surgery, therapy* Clinical Trials as Topic Combined Modality Therapy Cyclophosphamide / administration & dosage Female Fluorouracil / administration & dosage Humans Lymph Node Excision Lymphatic Metastasis Mastectomy* Menopause Methotrexate / administration & dosage Middle Aged Prednisone / administration & dosage* Random Allocation Tamoxifen / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/CMFP protocol; 10540-29-1/Tamoxifen; 50-18-0/Cyclophosphamide; 51-21-8/Fluorouracil; 53-03-2/Prednisone; 59-05-2/Methotrexate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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