| Randomised, controlled trial of spirometric changes in elderly people receiving timolol or betaxolol as initial treatment for glaucoma. | |
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MedLine Citation:
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PMID: 9613379 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To investigate respiratory and cardiovascular side effects in elderly people in the first 12 months after commencing topical beta antagonists. METHODS: 40 patients (mean age 74 years) were recruited to a randomised, masked study. Spirometry, pulse, and blood pressure were recorded before, 1 month, and 12 months after starting topical therapy with either timolol 0.5% twice daily or betaxolol 0.5% twice daily. RESULTS: After 1 month five of 20 patients allocated timolol and three of 20 given betaxolol had discontinued it for respiratory reasons, not always accompanied by symptoms. There were no significant differences in changes in mean values of spirometry, pulse, or blood pressure between groups. No further changes were made in therapy for respiratory reasons in the following year. One patient suffered a hypotensive stroke within 2 days of starting timolol. CONCLUSIONS: By performing spirometry before starting topical beta antagonist therapy and repeating it after 1 month most patients at risk of respiratory impairment can be identified. |
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Authors:
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P Diggory; A Cassels-Brown; A Vail; J S Hillman |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The British journal of ophthalmology Volume: 82 ISSN: 0007-1161 ISO Abbreviation: Br J Ophthalmol Publication Date: 1998 Feb |
Date Detail:
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Created Date: 1998-06-11 Completed Date: 1998-06-11 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0421041 Medline TA: Br J Ophthalmol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 146-9 Citation Subset: IM |
Affiliation:
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Department of Medicine for the Elderly, St James's University Hospital, Leeds. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antihypertensive Agents / adverse effects* Betaxolol / adverse effects* Double-Blind Method Female Glaucoma / drug therapy* Humans Intraocular Pressure Male Respiration Disorders / chemically induced* Spirometry Timolol / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 26839-75-8/Timolol; 63659-18-7/Betaxolol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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