Document Detail


Randomised controlled trial for efficacy of unfractionated heparin (UFH) versus low molecular weight heparin (LMWH) in thrombo-prophylaxis.
MedLine Citation:
PMID:  24968543     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
OBJECTIVE: To study if low dose Unfractionated heparin (UFH) is as effective and safe as Low-molecular weight heparin (LMWH) and also economical as a prophylactic agent for venous thromboembolism in medically ill patients.
METHODOLOGY: A prospective double blind randomised controlled trial consisting of 92 patients fulfilling the inclusion criteria who were admitted to Bangalore Baptist Hospital, Bengaluru, between March 2008 and July 2009 were randomised to receive Unfractionated heparin (UFH) or Low-molecular weight heparin (LMWH).
RESULTS: The result based on intention to treat (ITT)analysis with best outcome scenario: in the UFH arm there were 47 (97.9%) patients who had not developed DVT/PE as compared to 42 (95.5%) in the LMWH arm. The difference in proportion of patients who had not developed DVT/PE between UFH and LMWH was 2.4% (-5.0, 9.8). The results based on per protocol analysis: In the UFH arm there were 44 (97.8%) patients who had not developed DVT/PE as compared to 39 (95.1%) in the LMWH arm. The difference in proportion of patients who had not developed DVT/PE between the UFH and LMWH arm was 2.7% (-5.2, 10.5). Patients on UFH had higher major bleeding complications 4 (8.9%) as compared to 0 in LMWH arm. But with respect to other complications like thrombocytopenia (HIT) and mild or minimal bleeding both arms were comparable.
CONCLUSION: This study has demonstrated that low dose UFH is as effective as LMWH as a prophylactic agent for venous thromboembolism in medically ill patients and economical also.
Authors:
Sandeep V Ishi; M Lakshmi; Shailesh T Kakde; Kirti C Sabnis; Manjeera Jagannati; T S Girish; L Jeyaseelan; A M Cherian
Related Documents :
15561753 - Investigating patient exclusion bias in meta-analysis.
23343333 - What we can really expect from telemedicine in intensive diabetes treatment: 10 years l...
19961283 - Association between incidence of acute exacerbation and medication therapy in patients ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of the Association of Physicians of India     Volume:  61     ISSN:  0004-5772     ISO Abbreviation:  J Assoc Physicians India     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2014-06-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505585     Medline TA:  J Assoc Physicians India     Country:  India    
Other Details:
Languages:  eng     Pagination:  882-6     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  [The role of nitric oxide and NO-synthase in the pathogenesis of cerebral damage after subarachnoid ...
Next Document:  Comparison of demographic, clinical, radiological characteristics and comorbidities in mechanically ...