| Randomised controlled trial: comparison of colloid or crystalloid for partial exchange transfusion for treatment of neonatal polycythaemia. | |
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MedLine Citation:
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PMID: 9377132 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To compare the efficacy of using isotonic saline (crystalloid) or 5% albumin (colloid) as replacement fluid in partial exchange transfusion (PET) for the treatment of neonatal polycythaemia. METHODS: One hundred and two polycythaemic full term infants were randomly allocated to receive PET with either isotonic saline or 5% albumin. The criteria for PET were: (a) venous haematocrit > or = 0.7; or (b) venous haematocrit 0.65-0.69 with symptoms or signs attributable to polycythaemia. RESULTS: PET with either saline (n = 53) or 5% albumin (n = 50) resulted in a significant and sustained decline in haematocrit up to 24 hours after PET. Although the immediate haemodilution effect of isotonic saline was statistically smaller than that of 5% albumin (decline in haematocrit 19.3% vs 22.8% of pre-PET value), the difference was too small to be of any clinical significance, and the haematocrit at 4 or 24 hours after PET did not differ significantly between the two groups. PET with either replacement fluid was not associated with any complication. The serum sodium and potassium concentrations were not significantly affected by the PET in either group. CONCLUSIONS: Both isotonic saline and 5% albumin are effective when used as replacement fluid in PET for the treatment of neonatal polycythaemia. Isotonic saline, which is cheaper and free of infection, should be the replacement fluid of choice. |
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Authors:
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W Wong; T F Fok; C H Lee; P C Ng; K W So; Y Ou; K L Cheung |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Archives of disease in childhood. Fetal and neonatal edition Volume: 77 ISSN: 1359-2998 ISO Abbreviation: Arch. Dis. Child. Fetal Neonatal Ed. Publication Date: 1997 Sep |
Date Detail:
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Created Date: 1997-11-12 Completed Date: 1997-11-12 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 9501297 Medline TA: Arch Dis Child Fetal Neonatal Ed Country: ENGLAND |
Other Details:
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Languages: eng Pagination: F115-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Paediatrics, Prince of Wales Hospital, Shatin, Hong Kong, People's Republic of China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Albumins
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administration & dosage* Analysis of Variance Colloids Exchange Transfusion, Whole Blood / methods* Female Hematocrit Humans Infant, Newborn Isotonic Solutions Male Plasma Substitutes / administration & dosage* Polycythemia / therapy* Sodium Chloride / administration & dosage* Statistics, Nonparametric Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Albumins; 0/Colloids; 0/Isotonic Solutions; 0/Plasma Substitutes; 0/crystalloid solutions; 7647-14-5/Sodium Chloride |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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