Document Detail


Randomised controlled trial analysing supplementation with 250 versus 500 units of vitamin D3, sun exposure and surrounding factors in breastfed infants.
MedLine Citation:
PMID:  20861405     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The rate of non-compliance with vitamin D supplementation is as high as 45%. This is why randomised controlled trials are needed to analyse the response to low doses of vitamin D3.
OBJECTIVE: (1) To compare supplementation with 250 versus 500 units of vitamin D3 and (2) to analyse sun exposure time/ultraviolet B (UVB) exposure during the first 6 weeks of life.
DESIGN: 40 breastfed infants (skin photo-types I, II) were recruited in Berlin, Germany (52.5°N), during summer (n=20) and winter (n=20) and randomised into equal groups on either 250 or 500 units of vitamin D3 per day. Outcome measures were: parameters of vitamin D and bone metabolism at delivery and 6 weeks later, sun exposure time, UVB dosimetry and surrounding factors including maternal diet.
RESULTS: At delivery 25-hydroxy vitamin D levels were insufficient: 68 (53-83) nmol/l in each group. 6 weeks later levels were sufficient: 139 (114-164) nmol/l on 250 units of vitamin D3 per day and 151 (126-176) nmol/l on 500 units/day. There was no seasonal variation. Daily sun exposure time was 0.4-3.5 h and higher in summer. UVB exposure was 0.01-0.08 minimal erythema dose/day. Calcium levels were within normal.
CONCLUSIONS: In Berlin, Germany, supplementation with 250 units of vitamin D3 is sufficient for breastfed infants during their first 6 weeks of life in summer and winter. UVB exposure is very low throughout the year.
Authors:
Aris Siafarikas; Helmut Piazena; Uwe Feister; Max K Bulsara; Hans Meffert; Volker Hesse
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-09-22
Journal Detail:
Title:  Archives of disease in childhood     Volume:  96     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-20     Completed Date:  2011-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  England    
Other Details:
Languages:  eng     Pagination:  91-5     Citation Subset:  AIM; IM    
Affiliation:
Sana-Hospital Lichtenberg, Humboldt University, Berlin, Germany. aris.siafarikas@health.wa.gov.au
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MeSH Terms
Descriptor/Qualifier:
Anthropometry / methods
Bone and Bones / metabolism
Breast Feeding*
Cholecalciferol / administration & dosage*,  blood
Dietary Supplements
Dose-Response Relationship, Drug
Environmental Exposure / analysis
Female
Humans
Infant, Newborn
Maternal Nutritional Physiological Phenomena / physiology
Physical Examination / methods
Seasons
Sunlight*
Ultraviolet Rays
Vitamins / administration & dosage*
Chemical
Reg. No./Substance:
0/Vitamins; 67-97-0/Cholecalciferol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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