Document Detail

Randomised Diagnostic Accuracy Study of a Fully Automated Portable Device for Diagnosing Peripheral Arterial Disease by Measuring the Toe-brachial Index.
MedLine Citation:
PMID:  23122184     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To assess the accuracy of a fully automated portable device (APD) for diagnosing peripheral arterial disease (PAD) by measuring the toe-brachial index (TBI) and using mercury-in-silastic, strain-gauge plethysmography (SGP) as reference. DESIGN: Prospective, randomised, double-blinded diagnostic accuracy study. MATERIALS AND METHODS: A total of 204 consecutive patients with known or suspected PAD were randomly assigned to measurement of TBI by the portable device followed by the SGP technique or the opposite sequence. Finally, ankle-brachial index (ABI) was assessed by SGP. RESULTS: The APD showed a sensitivity of 98.8%, a specificity of 61.0%, a positive predictive value of 91.0% and a negative predictive value of 92.6% for detecting PAD compared to a full SGP test comprised of ABI and TBI. According to the SGP test, 35 patients (17.2%) had an ABI > 0.90 but a TBI < 0.70. Correlation analysis of the absolute toe pressures by the two methods showed an intraclass correlation coefficient of 0.937 (95% confidence interval (CI) 0.887-0.962) for right toe pressures and 0.939 (95% CI 0.908-0.958) for the left toe pressures. CONCLUSIONS: The APD showed excellent diagnostic test characteristics for detecting PAD compared to SGP. Furthermore, the APD had a good correlation in absolute toe pressures with SGP.
C Høyer; J Sandermann; L J Petersen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-30
Journal Detail:
Title:  European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery     Volume:  -     ISSN:  1532-2165     ISO Abbreviation:  Eur J Vasc Endovasc Surg     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-11-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9512728     Medline TA:  Eur J Vasc Endovasc Surg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.
Department of Clinical Physiology, Viborg Regional Hospital, DK-8800 Viborg, Denmark; Department of Health Science and Technology, Aalborg University, DK-9220 Aalborg, Denmark. Electronic address:
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