Document Detail


Random number generation evaluation in patients with systemic lupus erythematosus indicates a heterogeneous nature of central nervous system vulnerability.
MedLine Citation:
PMID:  16882594     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the vulnerability of the central nervous system (CNS) in patients with systemic lupus erythematosus (SLE). METHODS: Forty-eight patients with SLE, 58 with schizophrenia in remission and 39 healthy controls were enrolled in the study. Patients vocally generated 100 numbers in a random fashion, using numbers 0 to 9, and were evaluated with seriality scores. Patients with SLE were subgrouped according to differences in the presence of Raynaud's phenomenon, anti-phospholipid antibody, lupus activity, and a history of neuropsychiatric (NP) lupus, and these patients were also evaluated by comparison with their counterparts. RESULTS: In general, patients with SLE showed lower seriality scores than patients with schizophrenia, and higher seriality scores than normal controls. The scores of the patients with a history of NP lupus matched those with schizophrenia, and the scores of never having NP lupus matched those of the healthy controls. CONCLUSIONS: CNS vulnerability may be prolonged in patients who have a history of NP lupus even when they appear to be in normal NP status. The damage in random number generation (RNG) observed in patients with a history of NP lupus seemed equal to that found in those with schizophrenia, whereas those patients never having NP lupus appeared to be equal to the controls. The current study suggests a heterogeneous nature of SLE and prolonged damage, especially in CNS vulnerability, when evaluating with RNG.
Authors:
Y Matsukawa; M Nagashima; S Kamei; E Tanabe; S Takahashi; T Kojima; M Taira; K Morita; M Matsuura; S Sawada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of rheumatology     Volume:  35     ISSN:  0300-9742     ISO Abbreviation:  Scand. J. Rheumatol.     Publication Date:    2006 Jul-Aug
Date Detail:
Created Date:  2006-08-02     Completed Date:  2006-10-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0321213     Medline TA:  Scand J Rheumatol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  295-9     Citation Subset:  IM    
Affiliation:
Division of Haematology and Rheumatology, Department of Medicine, Nihon University of Medicine, Oyaguchi-Kamimachi, Itabashi, 173-8610, Tokyo, Japan. m-2000@mbk.ocn.ne.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Antiphospholipid Syndrome / physiopathology
Central Nervous System / physiopathology*
Female
Humans
Lupus Erythematosus, Systemic / physiopathology*
Lupus Vasculitis, Central Nervous System / physiopathology
Male
Middle Aged
Raynaud Disease / physiopathology
Schizophrenia / physiopathology

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