Document Detail


Ramping up the signal: promoting endurance training adaptation in skeletal muscle by nutritional manipulation.
MedLine Citation:
PMID:  25142094     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Mitochondrial biogenesis in skeletal muscle results from the cumulative effect of transient increases in mRNA transcripts encoding mitochondrial proteins in response to repeated exercise sessions. This process requires the coordinated expression of both nuclear and mitochondrial (mt) DNA genomes and is regulated, for the most part, by the peroxisome proliferator-activated receptor γ coactivator 1α. Several other exercise-inducible proteins also play important roles in promoting an endurance phenotype, including AMP-activated protein kinase, p38 mitogen-activated protein kinase and tumour suppressor protein p53. Commencing endurance-based exercise with low muscle glycogen availability results in greater activation of many of these signalling proteins compared with when the same exercise is undertaken with normal glycogen concentration, suggesting that nutrient availability is a potent signal that can modulate the acute cellular responses to a single bout of exercise. When exercise sessions are repeated in the face of low glycogen availability (i.e. chronic training), the phenotypic adaptations resulting from such interventions are also augmented.
Authors:
John A Hawley; James P Morton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  41     ISSN:  1440-1681     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-08-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  608-13     Citation Subset:  IM    
Copyright Information:
© 2014 Wiley Publishing Asia Pty Ltd.
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