Document Detail

Raman spectroscopy: a potential tool for early objective diagnosis of neoplasia in the oesophagus.
MedLine Citation:
PMID:  21826797     Owner:  NLM     Status:  MEDLINE    
There is a profound clinical need for a diagnostic tool that will enable clinicians to identify early neoplastic change in the oesophagus. Raman Spectroscopy (RS) has demonstrated the potential to provide non-invasive, rapid, objective diagnosis of endoscopically invisible precancerous oesophageal dysplasia in vitro. RS analyses biological material to identify highly specific biochemical information that can be used to influence clinical care. Raman spectroscopic mapping could provide automated assessment of tissue biopsies to aid histopathological diagnosis in vitro. Furthermore, the recent development of fibre-optic Raman probes has enabled endoscopic assessment of oesophageal mucosa in vivo. Accurate identification of dysplasia will enable targeted endoscopic resection of early lesions preventing the development of oesophageal cancer. This review summarises the development of Raman systems for use as laboratory based analytical adjuncts and endoscopic diagnostic tools in the distal oesophagus.
L Max Almond; Joanne Hutchings; Neil Shepherd; Hugh Barr; Nick Stone; Catherine Kendall
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Publication Detail:
Type:  Journal Article; Review     Date:  2011-08-08
Journal Detail:
Title:  Journal of biophotonics     Volume:  4     ISSN:  1864-0648     ISO Abbreviation:  J Biophotonics     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-29     Completed Date:  2012-01-25     Revised Date:  2014-03-14    
Medline Journal Info:
Nlm Unique ID:  101318567     Medline TA:  J Biophotonics     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  685-95     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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MeSH Terms
Barrett Esophagus / diagnosis,  pathology
Early Diagnosis*
Endoscopy / instrumentation,  methods
Esophageal Neoplasms / diagnosis*,  pathology
Risk Factors
Spectrum Analysis, Raman / instrumentation,  methods*
Grant Support
CSA/03/07/017//Department of Health

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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