| Raman microspectroscopy of melanosomes: the effect of long term light irradiation. | |
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MedLine Citation:
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PMID: 21800432 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Melanosomes are long lived organelles in retinal pigment epithelium cells and are primarily responsible for photoprotection. However, with aging or prolong light radiation, the function of melanosomes diminishes, which may be due to photobleaching of melanin pigments present in melanosomes. In this study, melanosomes were isolated from the retinal pigment epithelium cells and exposed to green light (532 nm), and the chemical changes were monitored using Raman microspectroscopy. Photochemical changes were recorded for different power levels and exposure times. The threshold power and the rate for irreversible photobleaching of melanosomes were calculated by fitting the experimental data with a proposed model. (© 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim). |
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Authors:
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Anushree Saha; Rajan Arora; Vladislav V Yakovlev; Janice M Burke |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-29 |
Journal Detail:
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Title: Journal of biophotonics Volume: - ISSN: 1864-0648 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101318567 Medline TA: J Biophotonics Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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School of Medicine, Case Western Reserve University, 2085 Adelbert Road, OH 44106, USA. anushree.saha@case.edu. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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