Document Detail

Raising Awareness about Chronic Intestinal Pseudo-Obstruction (CIPO): A Case Report Showing CIPO as Initial Manifestation of Atypical Seronegative Systemic Sclerosis.
MedLine Citation:
PMID:  23059804     Owner:  NLM     Status:  Publisher    
Only few case studies address pseudo-obstruction, a disorder - which often frustrates clinicians and patients due to an unclear diagnosis and limited therapeutic options. Thus, the aim of this paper is to investigate a relevant case concerning a patient presenting with symptoms of acquired chronic intestinal pseudo-obstruction (CIPO). After one year of extensive diagnostic tests and unsuccessful treatment with prokinetics, the patient underwent a subtotal ileocolectomy. The histology of the intestinal specimen revealed continuous atrophy and fibrosis mainly within the circular, inner muscle layer of muscularis propria of the ileum and colon. Even though serum markers were lacking, a subsequent skin biopsy showed signs of scleroderma supporting an initial diagnosis of intestinal involvement in systemic sclerosis. Despite treatment with steroids and methotrexate, the increasingly emaciated patient died. In conclusion, there is a bias against the publishing of pseudo-obstruction studies, in particular, due to the obscure underlying causes. To raise awareness of this problem, we call for clinicians to systematically generate comprehensive data about patients presenting these symptoms.
J Jäkel; J W Heise; N Gassler; C G Dietrich
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-11
Journal Detail:
Title:  Zeitschrift fur Gastroenterologie     Volume:  50     ISSN:  1439-7803     ISO Abbreviation:  Z Gastroenterol     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0033370     Medline TA:  Z Gastroenterol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1100-1103     Citation Subset:  -    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
Institute of Pathology, University Hospital of RWTH Aachen, Aachen, Germany.
Vernacular Title:
Mehr Beachtung für die chronische intestinale Pseudoobstruktion (CIPO): Ein Fallbericht mit CIPO als initiale Manifestation einer atypischen seronegativen Sklerodermie.
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