Document Detail

Raised tissue copper levels in oral submucous fibrosis.
MedLine Citation:
PMID:  10890553     Owner:  NLM     Status:  MEDLINE    
Oral submucous fibrosis (OSF) is a well-recognised-potentially malignant condition of the oral cavity associated with areca nut chewing. Areca nut has been shown to have a high copper content compared to other commonly eaten nuts, and chewing areca nut for 5-30 min significantly increases soluble copper in whole mouth fluids. Our aims were to determine if tissue and serum concentrations of copper were raised in patients with OSF as a result of chewing areca nut. A panel of buccal mucosal biopsies from patients with OSF from Nagpur, India, was used to measure the tissue concentrations of copper by mass absorption spectrometry (MAS). By MAS, the mean tissue copper level was 5.5+/-2.9 microg/g in the OSF specimens (n=11) compared with 4+/-1.9 microg/g in the non-areca chewing controls (n=7) (P=0.2). Energy dispersive x-ray microanalysis (EDX) was used to identify the presence and distribution of the metal element. EDX showed distinct peaks corresponding to copper (Kalpha 8.04 keV; Kbeta, 8.91 keV) in the epithelium (21/23) and in the connective tissue (17/23) of the OSF specimens compared to spectra obtained from control oral biopsies from non-areca chewing subjects (n=7). These findings were confirmed by secondary ion mass spectrometry (SIMS) analysis in a small number of samples. Serum copper (17.23+/-1.80 pmol/l), caeruloplasmin (0.32+/-0.04 g/l) levels and urinary copper (0.52+/-0.26 micromol/l) in OSF patients (n=14) were within the laboratory reference ranges. The finding of copper in OSF tissue supports the hypothesis of copper as an initiating factor in OSF, playing a role in stimulating fibrogenesis by the upregulation of lysyl oxidase activity.
C R Trivedy; K A Warnakulasuriya; T J Peters; R Senkus; V K Hazarey; N W Johnson
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology     Volume:  29     ISSN:  0904-2512     ISO Abbreviation:  J. Oral Pathol. Med.     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-10-18     Completed Date:  2000-11-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8911934     Medline TA:  J Oral Pathol Med     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  241-8     Citation Subset:  D; IM    
Department of Oral Medicine and Pathology, WHO Collaborating Centre for Oral Cancer and Precancer, London, England.
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MeSH Terms
Ceruloplasmin / analysis
Connective Tissue / chemistry,  pathology
Copper / analysis*,  blood,  urine
Electron Probe Microanalysis
Epithelium / chemistry,  pathology
Mass Spectrometry
Middle Aged
Mouth Mucosa / chemistry*,  pathology
Oral Submucous Fibrosis / metabolism*,  pathology
Plants, Medicinal
Saliva / chemistry
Spectrometry, Mass, Secondary Ion
Reg. No./Substance:
7440-50-8/Copper; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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