Document Detail


Raised plasma concentrations of platelet factor 4 (PF4) in Crohn's disease.
MedLine Citation:
PMID:  3570037     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plasma platelet factor 4 (PF4), secreted by the platelets, is an index of platelet aggregation and thromboembolic risk. The authors assessed PF4 in 20 patients with Crohn's disease (ileitis in 13 patients, ileocolitis in seven) and in 20 healthy volunteers. Disease activity was low (Crohn's Disease Activity Index less than 150) in 11 patients and high in nine. Radioimmunoassay of PF4 using Abbott's Kit was performed on one sample of plasma from each subject (nv less than or equal to 0.324 nmol/ml), (nv less than or equal to 10 ng/ml). A significantly higher concentration of PF4 was found in Crohn's disease patients: 4.625 +/- 1.1 nmol/ml (142.5 +/- 36 ng/ml) than in the control group: 0.189 +/- 0.07 nmol/ml (5.6 +/- 4.8 ng/ml) (Z = 5.396, p less than 0.0001). No correlation was present between PF4 levels and activity, the site of disease, or medical treatment with or without prednisone.
Authors:
M Simi; S Leardi; M T Tebano; M Castelli; F M Costantini; V Speranza
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gut     Volume:  28     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1987 Mar 
Date Detail:
Created Date:  1987-06-05     Completed Date:  1987-06-05     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  336-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Crohn Disease / blood*
Female
Humans
Male
Middle Aged
Platelet Factor 4 / analysis*
Chemical
Reg. No./Substance:
37270-94-3/Platelet Factor 4
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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