Document Detail

Raised factor VIII is associated with coronary thrombotic events.
MedLine Citation:
PMID:  9875127     Owner:  NLM     Status:  MEDLINE    
Coagulation is triggered during the onset of myocardial infarction, resulting in vascular occlusion. However, a causal role for individual haemostatic factors in the development of thrombotic occlusion is not established. Three cases (all relatively young women) are reported of raised factor VIII associated with myocardial infarction. Two patients presented acutely with myocardial infarction at a relatively young age with no preceding history of angina. The other patient had had venous thrombosis when young and activated protein C resistance (APCR), without the presence of factor V Leiden. A functional relation exists between APCR and factor VIII; therefore, raised factor VIII may contribute to APCR and the increased thrombotic risk in patients without factor V Leiden. Factor VIII is an important risk factor for atherothrombotic events, including sudden death, in patients with vascular disease. These cases support the association of raised factor VIII with acute thrombotic events, even in patients without significant underlying atheromatous disease.
D A Gorog; R Rakhit; D Parums; M Laffan; G J Davies
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  80     ISSN:  1355-6037     ISO Abbreviation:  Heart     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1999-01-13     Completed Date:  1999-01-13     Revised Date:  2008-11-20    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  415-7     Citation Subset:  AIM; IM    
Division of Cardiology, Imperial College School of Medicine, Hammersmith Hospital, London, UK.
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MeSH Terms
Activated Protein C Resistance / blood,  physiopathology
Coronary Angiography
Coronary Thrombosis / blood*,  physiopathology,  radiography
Factor VIII / metabolism*
Middle Aged
Myocardial Infarction / blood*,  physiopathology
Reg. No./Substance:
9001-27-8/Factor VIII

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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