Document Detail

Raised arterial pressure in parents of proteinuric insulin dependent diabetics.
MedLine Citation:
PMID:  3117203     Owner:  NLM     Status:  MEDLINE    
Arterial pressure is raised early in the subset of insulin dependent diabetics at risk of later development of progressive renal failure, suggesting that liability to arterial hypertension may play a part in the aetiology of diabetic kidney disease. Evidence for a genetic basis was therefore sought by measuring the blood pressures of the 26 surviving parents of 17 insulin dependent diabetic patients with proteinuria and comparing them with those of the parents of 17 matched insulin dependent diabetic patients without proteinuria selected from the same cohort. Systolic and diastolic pressures were significantly higher in parents of the proteinuric (mean (SD) 161 (27)/94 (14) mm Hg) than in parents of the non-proteinuric patients (146 (21)/86 (11) mm Hg). The difference between the sample mean blood pressures was 15 mm Hg (95% confidence interval 3.3 to 26.7 mm Hg) for systolic pressure and 8 mm Hg (95% confidence interval 0.8 to 15.2 mm Hg) for diastolic pressure. These differences were independent of age, sex, and adiposity. There was a significant correlation between the mean arterial pressures in the proteinuric patients and the higher mean blood pressure in their parents. High blood pressure in non-diabetic parents may be a marker of susceptibility to clinical nephropathy in their insulin dependent diabetic offspring.
G C Viberti; H Keen; M J Wiseman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British medical journal (Clinical research ed.)     Volume:  295     ISSN:  0267-0623     ISO Abbreviation:  Br Med J (Clin Res Ed)     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1987-12-14     Completed Date:  1987-12-14     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8302911     Medline TA:  Br Med J (Clin Res Ed)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  515-7     Citation Subset:  AIM; IM    
Unit for Metabolic Medicine, United Medical School of Guy's Hospital, London.
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MeSH Terms
Blood Pressure*
Diabetes Mellitus, Type 1 / complications,  physiopathology
Diabetic Nephropathies / etiology,  genetics*
Middle Aged
Proteinuria / etiology,  genetics*,  physiopathology
Risk Factors

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