| Rage signalling promotes intestinal tumourigenesis. | |
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MedLine Citation:
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PMID: 22469986 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Development of colon cancer is a multistep process that is regulated by intrinsic and extrinsic cellular signals. Extrinsic factors include molecular patterns that are derived from either pathogens (PAMPs) or cellular damage (DAMPs). These molecules can promote tumourigenesis by activation of the innate immune system, but the individual contribution of ligands and their receptors remains elusive. The receptor for advanced glycation end products (Rage) is a pattern recognition receptor that binds multiple ligands derived from a damaged cell environment such as Hmgb1 and S100 protein. Here we show that Rage signalling has a critical role in sporadic development of intestinal adenomas, as Apc(Min/+) Rage(-/-) mice are protected against tumourigenesis.Oncogene advance online publication, 2 April 2012; doi:10.1038/onc.2012.119. |
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Authors:
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J Heijmans; N V J A Büller; E Hoff; A A Dihal; T van der Poll; M A D van Zoelen; A Bierhaus; I Biemond; J C H Hardwick; D W Hommes; V Muncan; G R van den Brink |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-02 |
Journal Detail:
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Title: Oncogene Volume: - ISSN: 1476-5594 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8711562 Medline TA: Oncogene Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1] Tytgat Institute for Liver & Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands [2] Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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