| The raf inhibitor paradox: unexpected consequences of targeted drugs. | |
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MedLine Citation:
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PMID: 20227037 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Three papers in Cell and Nature now report that dimeric RAF is a plastic enzyme: blocking one ATP-binding site paradoxically stimulates the kinase activity of the other protomer. This occurs only in "primed" cells bearing activated RAS and WT RAF, explaining the selective efficacy of RAF inhibitors for RAF mutant cells. |
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Authors:
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Adrienne D Cox; Channing J Der |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cancer cell Volume: 17 ISSN: 1878-3686 ISO Abbreviation: Cancer Cell Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-15 Completed Date: 2010-06-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101130617 Medline TA: Cancer Cell Country: United States |
Other Details:
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Languages: eng Pagination: 221-3 Citation Subset: - |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA. adricox@med.unc.edu |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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