Document Detail

Radiotracers for fungal infection imaging.
MedLine Citation:
PMID:  20795767     Owner:  NLM     Status:  MEDLINE    
Invasive fungal infections are recognized as an important cause of morbidity and mortality in the immunocompromised host. Rapid initiation of adequate antifungal treatment is often hampered by the limitations of current diagnostic methods. This review encompasses the promises and limitations of newer tracers (believed to target the infectious agents), i.e., radiolabeled antimicrobial peptides, antifungals and chitin-specific agents, for fungal infection imaging by scintigraphy. In mice (99m)Tc-labeled peptides derived from human ubiquicidin (UBI29-41) and lactoferrin (hLF1-11) distinguished local Candida albicans and Aspergillus fumigatus infections from sterile inflammatory processes, but not from bacterial infections. Clinical trials showed that (99m)Tc-UBI29-41 can distinguish infections from inflammatory lesions with 80% specificity and 100% sensitivity. (99m)Tc-hLF1-11 was able to monitor the antifungal effects of fluconazole on C. albicans infections. Moreover, (99m)Tc-fluconazole proved to be an excellent tracer for C. albicans infections as it did not accumulate in bacterial infections and inflammatory processes. However this tracer poorly detected A. fumigatus infections. Furthermore, (123)I-chitinase and (99m)Tc-HYNIC-CBP21 accumulated in both C. albicans and A. fumigatus infections in mice at later time points. In conclusion, despite the recent advances in radiolabeled imaging techniques for invasive fungal infections, the search for better tracers for fungal infection imaging should be continued.
Antonella Lupetti; Mark G J de Boer; Paola Erba; Mario Campa; Peter H Nibbering
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-08-26
Journal Detail:
Title:  Medical mycology     Volume:  49 Suppl 1     ISSN:  1460-2709     ISO Abbreviation:  Med. Mycol.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-14     Completed Date:  2012-04-16     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  9815835     Medline TA:  Med Mycol     Country:  England    
Other Details:
Languages:  eng     Pagination:  S62-9     Citation Subset:  IM    
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MeSH Terms
Antifungal Agents / diagnostic use,  metabolism
Aspergillosis / diagnosis,  microbiology,  radionuclide imaging*
Aspergillus fumigatus / metabolism*,  pathogenicity
Candida albicans / metabolism*,  pathogenicity
Candidiasis / diagnosis,  microbiology,  radionuclide imaging*
Chitin / metabolism
Diagnosis, Differential
Fluconazole / diagnostic use,  metabolism
Peptide Fragments
Radioactive Tracers
Radiopharmaceuticals / diagnostic use*
Sensitivity and Specificity
Technetium / diagnostic use
Reg. No./Substance:
0/Antifungal Agents; 0/Peptide Fragments; 0/Radioactive Tracers; 0/Radiopharmaceuticals; 0/lactoferrin (1-11), human; 1398-61-4/Chitin; 7440-26-8/Technetium; 8VZV102JFY/Fluconazole; EC 3.4.21.-/Lactoferrin

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