Document Detail

Radiotherapy for supradiaphragmatic Hodgkin's disease: Determination of the proper fetal shielding conditions using Monte Carlo methodology.
MedLine Citation:
PMID:  21216645     Owner:  NLM     Status:  Publisher    
This study aimed to estimate fetal dose from mantle field irradiation with 6MV photons and to determine the proper fetal shielding conditions. The Monte Carlo N-particle code and mathematical phantoms representing pregnancy at the first, second and third trimesters of gestation were used to calculate fetal dose with or without the presence of a 5-cm-thick lead shield of dimensions 35×35cm(2). Fetal exposure was calculated for lead thicknesses of 2, 3, 4, 6, 7 and 8cm. The dependence of fetal dose upon the distance separating the shield from the beam edge and phantom's abdomen was investigated. Dose measurements were performed on a physical phantom using thermoluminescent dosimetry. The radiation dose to an unshielded and shielded fetus was 0.578-0.861% and 0.180-0.641% of the prescribed tumor dose, respectively, depending upon the gestational age. The lead thickness increase from 2 to 5cm led to a fetal dose reduction up to 23.4%. The use of 5- to 8-cm-thick lead resulted in dose values differing less than 4.5%. The shift of the lead from the closer to the more distant position relative to the field edge increased fetal dose up to 42.5%. The respective increase by changing the distance from the phantom's abdomen was 21.9%. The difference between dose calculations and measurements at specific points was 8.3±3.9%. The presented data may be used for fetal dose assessment with different shielding settings before treatment and, then, for the design and construction of the appropriate shielding device.
Michalis Mazonakis; Antonis Tzedakis; Charalambos Varveris; John Damilakis
Related Documents :
21224975 - A comparative study of efficacy of propofol auto-co-induction versus midazolam propofol...
8867715 - Resuscitation from cardiac arrest in cats: influence of epinephrine dosage on brain rec...
9702845 - Maximum tolerated dose and pharmacodynamics of eptastigmine in elderly healthy volunteers.
15266045 - Lack of pharmacokinetic or pharmacodynamic interaction between memantine and donepezil.
15279565 - Pharmacological aspects of (-)-deprenyl.
23828355 - Acetone extract from streptoverticillium sp., a bacterium isolated from brazilian cerra...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-7
Journal Detail:
Title:  Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)     Volume:  -     ISSN:  1724-191X     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9302888     Medline TA:  Phys Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2010 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.
Department of Medical Physics, Faculty of Medicine, University of Crete, P.O. Box 2208, 71003 Iraklion, Crete, Greece.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Clinicopathological findings and disease staging of feline infectious peritonitis: 51 cases from 200...
Next Document:  Patient dosimetry and a novel approach to establishing Diagnostic Reference Levels in dental radiolo...