Document Detail


Radiotherapy for supradiaphragmatic Hodgkin's disease: Determination of the proper fetal shielding conditions using Monte Carlo methodology.
MedLine Citation:
PMID:  21216645     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This study aimed to estimate fetal dose from mantle field irradiation with 6MV photons and to determine the proper fetal shielding conditions. The Monte Carlo N-particle code and mathematical phantoms representing pregnancy at the first, second and third trimesters of gestation were used to calculate fetal dose with or without the presence of a 5-cm-thick lead shield of dimensions 35×35cm(2). Fetal exposure was calculated for lead thicknesses of 2, 3, 4, 6, 7 and 8cm. The dependence of fetal dose upon the distance separating the shield from the beam edge and phantom's abdomen was investigated. Dose measurements were performed on a physical phantom using thermoluminescent dosimetry. The radiation dose to an unshielded and shielded fetus was 0.578-0.861% and 0.180-0.641% of the prescribed tumor dose, respectively, depending upon the gestational age. The lead thickness increase from 2 to 5cm led to a fetal dose reduction up to 23.4%. The use of 5- to 8-cm-thick lead resulted in dose values differing less than 4.5%. The shift of the lead from the closer to the more distant position relative to the field edge increased fetal dose up to 42.5%. The respective increase by changing the distance from the phantom's abdomen was 21.9%. The difference between dose calculations and measurements at specific points was 8.3±3.9%. The presented data may be used for fetal dose assessment with different shielding settings before treatment and, then, for the design and construction of the appropriate shielding device.
Authors:
Michalis Mazonakis; Antonis Tzedakis; Charalambos Varveris; John Damilakis
Related Documents :
21224975 - A comparative study of efficacy of propofol auto-co-induction versus midazolam propofol...
8867715 - Resuscitation from cardiac arrest in cats: influence of epinephrine dosage on brain rec...
9702845 - Maximum tolerated dose and pharmacodynamics of eptastigmine in elderly healthy volunteers.
15266045 - Lack of pharmacokinetic or pharmacodynamic interaction between memantine and donepezil.
15279565 - Pharmacological aspects of (-)-deprenyl.
23828355 - Acetone extract from streptoverticillium sp., a bacterium isolated from brazilian cerra...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-7
Journal Detail:
Title:  Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)     Volume:  -     ISSN:  1724-191X     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9302888     Medline TA:  Phys Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2010 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Department of Medical Physics, Faculty of Medicine, University of Crete, P.O. Box 2208, 71003 Iraklion, Crete, Greece.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Clinicopathological findings and disease staging of feline infectious peritonitis: 51 cases from 200...
Next Document:  Patient dosimetry and a novel approach to establishing Diagnostic Reference Levels in dental radiolo...