Document Detail

Radiotherapy for life-threatening mediastinal hemangioma with Kasabach-Merritt syndrome.
MedLine Citation:
PMID:  16453298     Owner:  NLM     Status:  MEDLINE    
Kasabach-Merritt Syndrome (KMS) originally referred to a hemangioma associated with life-threatening thrombocytopenia and a consumption coagulopathy. Treatment includes surgery, steroids, and alpha interferon. However response may be unsatisfactory and mortality rates of 10-37% have been reported. We report a case of a 4-month-old male whose disease had not responded to steroids and alpha interferon. He required ventilation, and his condition was deteriorating. It was thought that he would probably die of his condition. He was treated with 9 Gy in three fractions weekly of radiotherapy (RT). Clinical response was good and he is well and free from progression 4 years and 7 months after RT. A review of the literature on the role of RT in the management of hemangiomas is presented.
Michelle Kwok-Williams; Zuleima Perez; Roly Squire; Adam Glaser; Stephanie Bew; Roger Taylor
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric blood & cancer     Volume:  49     ISSN:  1545-5009     ISO Abbreviation:  Pediatr Blood Cancer     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-08-27     Completed Date:  2007-10-11     Revised Date:  2009-01-12    
Medline Journal Info:
Nlm Unique ID:  101186624     Medline TA:  Pediatr Blood Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  739-44     Citation Subset:  IM    
Copyright Information:
(c) 2007 Wiley-Liss, Inc.
Department of Clinical Oncology, Cookridge Hospital, Leeds, United Kingdom.
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MeSH Terms
Hemangioma / diagnosis,  radiotherapy*
Magnetic Resonance Imaging
Mediastinum / pathology*
Platelet Count
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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