Document Detail


Radiotherapy of human sarcoma promotes an intratumoral immune effector signature.
MedLine Citation:
PMID:  23861514     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: The tumor immune microenvironment plays a crucial role in the development and progression of cancer. Sarcomas are a group of heterogeneous soft tissue malignancies that are often treated with radiotherapy as a part of the treatment concept. There is increasing evidence that radiotherapy leads to alterations in the tumor microenvironment, particularly with respect to the immune infiltrate. The present study has been carried out to develop a better understanding of such changes following radiotherapy.
EXPERIMENTAL DESIGN: We retrospectively analyzed the expression of 35 immune response-related genes by qRT-PCR analysis and immunohistochemistry on paired formalin-fixed paraffin-embedded tumor samples from 38 sarcoma patients before and after radiotherapy.
RESULTS: We observed that radiotherapy results in a significant upregulation of several immune effectors and cancer-testis antigens and a concomitant downregulation of immune suppressors, indicating that radiotherapy may support the immune defense in sarcomas.
CONCLUSIONS: These novel findings may have implications for the design of therapeutic regimens which exploite the immune system in sarcoma patients by combining standard radiotherapy with immunotherapeutic strategies.
Authors:
Anu Sharma; Beata Bode; Holger Moch; Michal Okoniewski; Alexander Knuth; Lotta von Boehmer; Maries van den Broek
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-7-16
Journal Detail:
Title:  Clinical cancer research : an official journal of the American Association for Cancer Research     Volume:  -     ISSN:  1078-0432     ISO Abbreviation:  Clin. Cancer Res.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-7-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9502500     Medline TA:  Clin Cancer Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Oncology, University Hospital Zurich.
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