Document Detail

Radiotherapy dose-fractionation schedules. Hyperfractionation and accelerated treatment regimens.
MedLine Citation:
PMID:  1944104     Owner:  NLM     Status:  MEDLINE    
It has become increasingly evident that conventional, once-daily, radiotherapy dose-fractionation schedules, developed over the years on the basis of observed normal tissue reactions, may not be ideal for all clinical situations. Differences in kinetics between normal and malignant tissues, especially repair of radiation injury in normal tissues and repopulation in tumors, suggest modifications to conventional dose-fractionation schedules that might be expected to result in an improved therapeutic ratio. Of these, hyperfractionation and accelerated treatment regimens appear to hold the most promise. The theoretical basis for these altered schedules is reviewed as is the clinical experience accumulated to date. The implications for treatment of children with brain tumors are presented.
C R Freeman; S Lehnert
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neurologic clinics     Volume:  9     ISSN:  0733-8619     ISO Abbreviation:  Neurol Clin     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-12-17     Completed Date:  1991-12-17     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8219232     Medline TA:  Neurol Clin     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  351-62     Citation Subset:  IM    
Division of Radiation Oncology, McGill University, Montreal, Quebec.
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MeSH Terms
Brain Neoplasms / radiotherapy*
Cell Survival / radiation effects
DNA Damage / radiation effects
Radiotherapy Dosage
Radiotherapy, High-Energy / methods*
Tumor Cells, Cultured / radiation effects

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