| Radiosynthesis of carbon-11-labeled camptothecin derivatives as potential positron emission tomography tracers for imaging of topoisomerase I in cancers. | |
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MedLine Citation:
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PMID: 15993064 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Four carbon-11-labeled camptothecin derivatives, 9-[11C]methoxy-20(S)-camptothecin ([11C]5), 10-[11C]methoxy-20(S)-camptothecin ([11C]7), 9-nitro-10-[11C]methoxy-20(S)-camptothecin ([11C]9), and 9-[([11C]trimethylamino)methyl]-10-hydroxy-20(S)-camptothecin ([11C]11), have been synthesized as potential positron emission tomography tracers for imaging of topoisomerase I in cancers. |
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Authors:
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Mingzhang Gao; Kathy D Miller; George W Sledge; Qi-Huang Zheng |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 15 ISSN: 0960-894X ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-08-02 Completed Date: 2005-10-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 3865-9 Citation Subset: IM |
Affiliation:
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Department of Radiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Camptothecin
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chemical synthesis,
diagnostic use* Carbon Radioisotopes / diagnostic use* DNA Topoisomerases, Type I / diagnostic use* Humans Neoplasms / radionuclide imaging* Positron-Emission Tomography / methods* Radionuclide Imaging / methods Radiopharmaceuticals / chemical synthesis Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Carbon Radioisotopes; 0/Radiopharmaceuticals; 7689-03-4/Camptothecin; EC 5.99.1.2/DNA Topoisomerases, Type I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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