Document Detail

Radiosynthesis of carbon-11-labeled camptothecin derivatives as potential positron emission tomography tracers for imaging of topoisomerase I in cancers.
MedLine Citation:
PMID:  15993064     Owner:  NLM     Status:  MEDLINE    
Four carbon-11-labeled camptothecin derivatives, 9-[11C]methoxy-20(S)-camptothecin ([11C]5), 10-[11C]methoxy-20(S)-camptothecin ([11C]7), 9-nitro-10-[11C]methoxy-20(S)-camptothecin ([11C]9), and 9-[([11C]trimethylamino)methyl]-10-hydroxy-20(S)-camptothecin ([11C]11), have been synthesized as potential positron emission tomography tracers for imaging of topoisomerase I in cancers.
Mingzhang Gao; Kathy D Miller; George W Sledge; Qi-Huang Zheng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  15     ISSN:  0960-894X     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-08-02     Completed Date:  2005-10-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  3865-9     Citation Subset:  IM    
Department of Radiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
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MeSH Terms
Camptothecin / chemical synthesis,  diagnostic use*
Carbon Radioisotopes / diagnostic use*
DNA Topoisomerases, Type I / diagnostic use*
Neoplasms / radionuclide imaging*
Positron-Emission Tomography / methods*
Radionuclide Imaging / methods
Radiopharmaceuticals / chemical synthesis
Structure-Activity Relationship
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Radiopharmaceuticals; 7689-03-4/Camptothecin; EC Topoisomerases, Type I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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