Document Detail

Radiosynoviorthesis (RSO): influencing factors and therapy monitoring.
MedLine Citation:
PMID:  19039551     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the effectiveness of radiosynoviorthesis (RSO) in relation to joint type and underlying disease by both self-assessment of patients and scintigraphic assessment to determine conditions under which RSO might be preferable to the sole intra-articular corticoid injection. METHODS: Radiosynoviorthesis was performed on 136 patients for 424 joints [242 small, 130 medium-sized, and 52 large joints; 313 with rheumatoid arthritis (RA) and 111 with osteoarthritis (OA)]. The success of RSO was evaluated after 12 months by patients' estimation, and in 35 patients for 157 joints additionally by two-phase bone scintigraphy. The relative change in the scintigraphic uptake was compared with the patients' estimation. RESULTS: The subjectively estimated success rates for the small, medium-sized, and large joints were 89% (215/242), 86% (112/130), and 79% (41/52), and for RA and OA 89% (280/313) and 79% (88/111), respectively. The scintigraphically determined response rates for small and medium-sized joints were 81% (86/106) and 69% (35/51), respectively. There was a mismatch between patients' assessment and scintigraphic assessments in 18% (28/157) with 6 false-negative and 22 false-positive estimations using scintigraphy as the standard of reference. CONCLUSIONS: The success of RSO is higher in patients with RA than in patients with OA. For the finger, ankle, and wrist joints in RA, RSO is so promising that we would like to advocate its preference over the sole intraarticular corticoid injection. Perfusion bone scintigraphy can be used for therapy monitoring and earlier switching to RSO by showing that other therapies have failed.
Lidiya Zuderman; Knut Liepe; Klaus Zöphel; Michael Andreeff; Joerg Kotzerke; Wolfgang Luboldt
Publication Detail:
Type:  Journal Article     Date:  2008-11-28
Journal Detail:
Title:  Annals of nuclear medicine     Volume:  22     ISSN:  0914-7187     ISO Abbreviation:  Ann Nucl Med     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-28     Completed Date:  2009-01-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913398     Medline TA:  Ann Nucl Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  735-41     Citation Subset:  IM    
Clinic and Policlinic of Nuclear Medicine, University Hospital Dresden, Fetscherstr. 74, 01307, Dresden, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Arthritis / radionuclide imaging*,  radiotherapy*
Middle Aged
Reproducibility of Results
Sensitivity and Specificity
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Maximal safe dose of I-131 after failure of standard fixed dose therapy in patients with differentia...
Next Document:  Frequency and characteristics of extremely low accumulation of 123I-metaiodobenzylguanidine (MIBG) i...