Document Detail

Radiosurgery from the brain to the spine: 20 years experience.
MedLine Citation:
PMID:  18642653     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Radiosurgery evolved from brain to spine. Mechanical and computer advances in linear accelerator (LINAC) radiosurgery apply precise single/fractional stereotactic radiation to multiple pathologies. METHODS: During a 10-year span the senior author used proton-beam radiosurgery in over 300 lesions, followed by gamma-knife, adapted and dedicated LINACS, including cyber-knife, in another 700 patients. The last 10 years, experience was accumulated with the Novalis in over 3,000 patients. Novalis uses a beam-shaper in a high-speed delivery LINAC. It operates using conventional circular arc, conformal static beam, dynamic conformal or intensity modulated modes. Patients treated with Novalis at the UCLA since 1997 were evaluated regarding effectiveness, complications and failure. These results were compared with previous 1997 data. RESULTS: Over 4,000 patients with trigeminal neuralgia/intractable pain, arteriovenous malformations/angiomas, metastases, ependymomas, gliomas, meningiomas hemangiopericytomas, schwannomas, adenomas, hemangioblastomas, and chordoma were treated. Spinal lesions were treated with frameless stereotaxis and on-line precision checks. Treatment was expeditious, comfortable and with reduced complications. Success is similar or superior to published data. Reduced treatment time of complex lesions and highly homogeneous dose compares favorably to other radiosurgery. CONCLUSIONS: The senior author's experience validates the novel shaped-beam approach. Long-term follow-up supports safety and effectiveness and capability to treat brain and spine.
A A F De Salles; A A Gorgulho; M Selch; J De Marco; N Agazaryan
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Acta neurochirurgica. Supplement     Volume:  101     ISSN:  0065-1419     ISO Abbreviation:  Acta Neurochir. Suppl.     Publication Date:  2008  
Date Detail:
Created Date:  2008-07-22     Completed Date:  2008-09-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100962752     Medline TA:  Acta Neurochir Suppl     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  163-8     Citation Subset:  IM    
Division of Neurosurgery, David Geffen School of Medicine, University of California at Los Angeles, CA 90095-7039 USA.
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MeSH Terms
Brain / surgery*
Brain Diseases / classification,  pathology*,  surgery*
Intracranial Arteriovenous Malformations
Longitudinal Studies
Magnetic Resonance Imaging / methods
Radiosurgery / methods*,  statistics & numerical data
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted
Retrospective Studies
Spine / surgery*
Trigeminal Neuralgia / surgery

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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