Document Detail

Radiosurgery of brain cavernomas - long-term results.
MedLine Citation:
PMID:  23258519     Owner:  NLM     Status:  In-Data-Review    
The radiosurgery of cavernomas remains a controversial issue. The only way to verify the positive effect of the treatment is by clinical observation during a longer follow-up period, where a decreased annual risk of rebleeding should be observed after the latent interval inherent to radiosurgery. Besides this, an improvement in clinical symptoms (e.g. secondary epilepsy) and regression of the treated lesion might also be observed. In a group of 112 patients with brain cavernomas treated in our centre between 1992 and 2000 with the marginal dose of a median 16 Gy, the risk of bleeding decreased from 2% before the treatment to 0.5% after 2 years' latent interval (median follow-up 84 months). A decrease in the extent of the cavernoma was observed in 53% of cases and an increase in 6.4%. Epilepsy, if present before the treatment, improved in 45% of cases. The risk of temporary and permanent morbidity caused by radiosurgery was 14.6 and 0.9%, respectively. This morbidity can be reduced by a lower marginal dose, and future studies should show if repeated radiosurgery decreases the risks from a natural course of the disease in those cases where the initial radiosurgery failed.
Roman Liscak
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Publication Detail:
Type:  Journal Article     Date:  2012-12-11
Journal Detail:
Title:  Progress in neurological surgery     Volume:  27     ISSN:  1662-3924     ISO Abbreviation:  Prog Neurol Surg     Publication Date:  2013  
Date Detail:
Created Date:  2012-12-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0076033     Medline TA:  Prog Neurol Surg     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  147-56     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 S. Karger AG, Basel.
Na Homolce Hospital, Prague, Czech Republic.
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