Document Detail


Radiosensitization of p53-Deficient Lung Cancer Cells by Pre-treatment with Cytostatic Compounds.
MedLine Citation:
PMID:  22493354     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Background/Aim: This study specifies a strategy to improve radiotherapy by partial synchronization of p53-deficient cancer cells (FaDu and H1299) in mitosis using taxol, with protecting p53 wild-type cells (A549) by the prior administration of cytostatic compounds. Cytotoxic and cytostatic effects of ionizing radiation, cisplatin, doxorubicin and taxol, administrated alone or in combination were investigated in vitro by flow cytometry. RESULTS: A protective effect of doxorubicin but not cisplatin was found after administration of triple sequence with ionizing radiation and taxol. It was found that preliminary administration of doxorubicin induced growth arrest and protected A549 cells from the taxol/radiation treatment, while simultaneously killing FaDu and H1299 cells. CONCLUSION: The proposed therapeutic strategy allows protection of p53 wild-type cells and selectively increases radiosensitivity of p53-deficient cancer cells.
Authors:
Sergey V Tokalov; Nasreddin Abolmaali
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  32     ISSN:  1791-7530     ISO Abbreviation:  Anticancer Res.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  1239-43     Citation Subset:  IM    
Affiliation:
Development and Regeneration Department, Foundation Caubet-CIMERA, Ctra. de Soller km 12, 071100 Bunyola, Ballearic Islands, Spain. Sergey.Tokalov@googlemail.com.
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