| Radiosensitization by gold nanoparticles. | |
| | |
MedLine Citation:
|
PMID: 23359187 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Recent years brought increasing use of gold nano particles (GNP) as a model platform for interaction of irradiation and GNPs aiming radiosensitization. Endocytosis seems to be one of the major pathways for cellular uptake of GNPs. Internalization mechanism of GNPs is likely receptor-mediated endocytosis, influenced by GNP size, shape, its coating and surface charging. Many showed that DNA damage can occur as a consequence of metal-enhanced production of low energy electrons, Auger electrons and alike. Kilovoltage radiotherapy (RT) carries significantly higher dose enhancement factor (DEF) that is observed with megavoltage irradiations, the latter usually been at the order of 1.1-1.2. Higher gold concentrations seem to carry higher risk of toxicity, while with lower concentrations the DEF can be reduced. Adding a chemotherapeutic agent could increase level of enhancement. Clinical trials are eagerly awaited with a promise of gaining more knowledge deemed necessary for more successful transition to widespread clinical practice. |
| | |
Authors:
|
B Jeremic; A R Aguerri; N Filipovic |
Related Documents
:
|
23448977 - Synthesis of reduced graphene oxide/ceo2 nanocomposites and their photocatalytic proper... 8836167 - Viscosity of rat adrenocortical lipids in different functional states: morphological ch... 8215797 - Development of quasi-multicellular bodies of treponema denticola. 209657 - Light and electron microscopic observations on the relationship between hirano bodies, ... 19113357 - Monodisperse microisland formation on ni/ru(0001) monolayers. 16351197 - Resonant tunneling in nanocolumns improved by quantum collimation. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-1-29 |
Journal Detail:
|
Title: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico Volume: - ISSN: 1699-3055 ISO Abbreviation: Clin Transl Oncol Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-1-29 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101247119 Medline TA: Clin Transl Oncol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
BioIRC, Bioengineering R&D Centre, Prvoslava Stojanovica 6, 34000, Kragujevac, Serbia, nebareje@gmail.com. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinical research in individual information of celiac artery CT imaging and gastric cancer surgery.
Next Document: CUG-binding protein 1 (CUGBP1) expression and prognosis of non-small cell lung cancer.