Document Detail

Radiosensitization by gold nanoparticles.
MedLine Citation:
PMID:  23359187     Owner:  NLM     Status:  Publisher    
Recent years brought increasing use of gold nano particles (GNP) as a model platform for interaction of irradiation and GNPs aiming radiosensitization. Endocytosis seems to be one of the major pathways for cellular uptake of GNPs. Internalization mechanism of GNPs is likely receptor-mediated endocytosis, influenced by GNP size, shape, its coating and surface charging. Many showed that DNA damage can occur as a consequence of metal-enhanced production of low energy electrons, Auger electrons and alike. Kilovoltage radiotherapy (RT) carries significantly higher dose enhancement factor (DEF) that is observed with megavoltage irradiations, the latter usually been at the order of 1.1-1.2. Higher gold concentrations seem to carry higher risk of toxicity, while with lower concentrations the DEF can be reduced. Adding a chemotherapeutic agent could increase level of enhancement. Clinical trials are eagerly awaited with a promise of gaining more knowledge deemed necessary for more successful transition to widespread clinical practice.
B Jeremic; A R Aguerri; N Filipovic
Related Documents :
23646607 - Synthesis of rhombic dodecahedral gold nanocrystals by dimethylformamide reduction.
22938257 - Molecular layers of znpc and fepc on au(111) surface: charge transfer and chemical inte...
23797807 - Novel kinetic trapping in charged colloidal clusters due to self-induced surface charge...
23368487 - Atomic and electronic structure of the batio_{3}(001) (sqrt[5]×sqrt[5])r26.6° surface...
19366197 - Fret pair printing of fluorescent proteins.
18237147 - Toward atomic-scale bright-field electron tomography for the study of fullerene-like na...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-29
Journal Detail:
Title:  Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico     Volume:  -     ISSN:  1699-3055     ISO Abbreviation:  Clin Transl Oncol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101247119     Medline TA:  Clin Transl Oncol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
BioIRC, Bioengineering R&D Centre, Prvoslava Stojanovica 6, 34000, Kragujevac, Serbia,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Clinical research in individual information of celiac artery CT imaging and gastric cancer surgery.
Next Document:  CUG-binding protein 1 (CUGBP1) expression and prognosis of non-small cell lung cancer.