Document Detail

Radiosensitization by dimethylbenzanthracene, diphenylcyclopropenone and aminoanthraquinones.
MedLine Citation:
PMID:  7473893     Owner:  NLM     Status:  MEDLINE    
Radiosensitization of mice by dimethylbenzanthracene, diphenylcyclopropenone and aminoanthraquinones was investigated in a model where survival time after lethal radiation was scored. Survival time was shortened by nontoxic doses of the chemicals. The used in vivo system confirmed the radiosensitizing potential of dimethylbenzanthracene reported previously with in vitro studies. Moreover, radiosensitizing properties of diphenylcyclopropenone and aminoanthraquinones could be demonstrated. The sensitizing interaction of these chemicals with radiation adds a new facet to their toxicological spectrum and could, by enhancing radiation effects, influence estimates of risk. On the other hand, diphenylcyclopropenone or aminoanthraquinones deserve consideration as topical sensitizers in conditions where radiation is indicated to treat cutaneous malignancies.
G L Floersheim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of toxicological sciences     Volume:  20     ISSN:  0388-1350     ISO Abbreviation:  J Toxicol Sci     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-11-27     Completed Date:  1995-11-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7805798     Medline TA:  J Toxicol Sci     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  149-54     Citation Subset:  IM    
Department of Research, University Hospitals, Basel, Switzerland.
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MeSH Terms
9,10-Dimethyl-1,2-benzanthracene / pharmacology
Anthraquinones / pharmacology
Cyclopropanes / pharmacology
Gamma Rays
Mice, Inbred C3H
Radiation Injuries, Experimental*
Radiation-Sensitizing Agents / pharmacology*
Survival Rate
Reg. No./Substance:
0/Anthraquinones; 0/Cyclopropanes; 0/Radiation-Sensitizing Agents; 117-79-3/2-aminoanthraquinone; 57-97-6/9,10-Dimethyl-1,2-benzanthracene; 82-45-1/1-aminoanthraquinone; 886-38-4/diphenylcyclopropenone

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