Document Detail

Radiosensitivity of tumor cells. Oncogenes and apoptosis.
MedLine Citation:
PMID:  11302264     Owner:  NLM     Status:  MEDLINE    
The success of treatment of cancer patients by radiotherapy largely depends on tumor radiosensitivity. Several molecular factors that determine the sensitivity of tumor cells to ionizing radiation have been identified during the last couple of years. Some of these factors are known as oncogenes and tumor suppressor genes. This review focuses on the influence of some of these molecular factors on a major determinant of radiosensitivity: i.e. programmed cell death or apoptosis. The crucial molecular step in ionizing radiation-induced apoptosis is the release of mitochondrial cytochrome c into the cell's cytosol. The ways the tumor suppressor protein p53, as well as the oncogenes ras and raf, c-myc and Bcl-2 can influence this process at different stages are presented. As will be discussed, the result of activation of an oncoprotein on tumor radiosensitivity depends on its mechanism of action and on the presence of other (oncogenic) factors, since complex interactions among many molecular factors determine the delicate balance between cell proliferation and cell death. The ongoing identification and characterization of factors influencing apoptosis will eventually make it possible to predict tumor radiosensitivity and thereby improve cancer treatment.
L T Peltenburg
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR)     Volume:  44     ISSN:  1125-0135     ISO Abbreviation:  Q J Nucl Med     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-04-13     Completed Date:  2001-05-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9512274     Medline TA:  Q J Nucl Med     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  355-64     Citation Subset:  IM    
Department of Clinical Oncology, Leiden University Medical Center, The Netherlands.
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MeSH Terms
Apoptosis / genetics,  radiation effects*
Genes, Tumor Suppressor / physiology
Neoplasms / genetics*,  pathology,  radiotherapy*
Proto-Oncogenes / physiology*
Radiation Tolerance / genetics*

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