| Radioprotective effects of hesperidin against genotoxicity induced by gamma-irradiation in human lymphocytes. | |
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MedLine Citation:
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PMID: 19193695 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The radioprotective effect of hesperidin against genotoxicity induced by gamma-irradiation has been investigated in vivo/in vitro in cultured blood lymphocytes from human volunteers. Peripheral blood samples were collected at 0 (10 min before) and at 1, 2 and 3 h after a single oral ingestion of 250 mg hesperidin. At each time point, the whole blood was exposed in vitro to 150 cGy of (60)Co gamma-irradiation and then the lymphocytes were cultured with mitogenic stimulation to determine the micronuclei in cytokinesis-blocked binucleated cells. For each volunteer, the results showed a significant increase in the incidence of micronuclei after exposure of cells to gamma-irradiation as compared to control samples. The lymphocytes in the blood samples collected at 1 h after hesperidin ingestion and exposed in vitro to gamma-rays exhibited a significant decrease in the incidence of micronuclei, compared with similarly irradiated lymphocytes from blood samples collected at 0 h. The maximum protection and decrease in frequency of micronuclei (33%) was observed at 1 h after ingestion of hesperidin. These data have important application for the protection of human lymphocytes from the genetic damage and side effects induced by gamma-irradiation in patients undergoing radiotherapy. |
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Authors:
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Seyed Jalal Hosseinimehr; Aziz Mahmoudzadeh; Amirhossein Ahmadi; Soheila Mohamadifar; Shahram Akhlaghpoor |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-02-04 |
Journal Detail:
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Title: Mutagenesis Volume: 24 ISSN: 1464-3804 ISO Abbreviation: Mutagenesis Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-30 Completed Date: 2009-06-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8707812 Medline TA: Mutagenesis Country: England |
Other Details:
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Languages: eng Pagination: 233-5 Citation Subset: IM |
Affiliation:
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Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. sjhosseinim@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Gamma Rays* Hesperidin / pharmacology* Humans Lymphocytes / radiation effects* Micronucleus Tests Mutation / drug effects*, radiation effects Radiation-Protective Agents / pharmacology* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Radiation-Protective Agents; 520-26-3/Hesperidin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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