| Radioprotective effects of antioxidative plant flavonoids in mice. | |
| | |
MedLine Citation:
|
PMID: 8657176 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Radioprotective effects of tea infusions and plant flavonoids were investigated by using the micronucleus test for anticlastogenic activity and the thiobarbituric acid assay for antioxidative activity. A single gastric intubation of rooibos tea (Aspalathus linearis) infusion at 1 ml per mouse 2 h prior to gama-ray irradiation (1.5 Gy) reduced the frequency of micronucleated reticulocytes (MNRETs). After the fractionation of rooibos tea infusion, the flavonoid fraction was found to be most anticlastogenic and antioxidative. From this fraction, luteolin was isolated as an effective component. Then, anticlastogenic effects of 12 flavonoids containing luteolin and their antioxidative activities against lipid peroxidation by Fenton's reagent were examined. A good correlation (r=0.717) was observed between both activities. Luteolin showed the most effective potency. A gastric intubation of luteolin (10 micromoles/kg) 2 h prior to gamma-ray irradiation (6 Gy) suppressed lipid peroxidation in mouse bone marrow and spleen and a trend of protective effect of luteolin against the decrease of endogenous ascorbic acid in mouse bone marrow after gamma-ray irradiation (3 Gy) was observed. These results suggest that plant flavonoids, which show antioxidative potency in vitro, work as antioxidants in vivo and their radioprotective effects may be attributed to their scavenging potency towards free radicals such as hydroxyl radicals. Therefore, the flavonoids contained in tea, vegetables and fruits seem to be important as antioxidants in the human diet. |
| | |
Authors:
|
K Shimoi; S Masuda; B Shen; M Furugori; N Kinae |
Related Documents
:
|
14759156 - Ferulic acid release and 4-vinylguaiacol formation during brewing and fermentation: ind... 19947176 - Free phenolic acids in ruta graveolens l. in vitro culture. 16551366 - Biosynthesis of plant-specific stilbene polyketides in metabolically engineered escheri... 18781766 - Preservation of kombucha tea-effect of temperature on tea components and free radical s... 18947836 - Sorption of selenium(iv) onto magnetite in the presence of silicic acid. 17074506 - Maldi tof/tof tandem mass spectrometry as a new tool for amino acid analysis. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Mutation research Volume: 350 ISSN: 0027-5107 ISO Abbreviation: Mutat. Res. Publication Date: 1996 Feb |
Date Detail:
|
Created Date: 1996-07-26 Completed Date: 1996-07-26 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0400763 Medline TA: Mutat Res Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 153-61 Citation Subset: IM |
Affiliation:
|
Laboratory of Food Hygiene, School of Food and Nutritional Sciences, University of Shizuoka, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antimutagenic Agents / chemistry, isolation & purification, pharmacology* Antioxidants / chemistry, isolation & purification, pharmacology* Beverages DNA Damage / genetics Flavonoids / isolation & purification, pharmacology* Fruit Gamma Rays / adverse effects Lipid Peroxidation Luteolin Mice Micronucleus Tests Mutagens / toxicity Plant Extracts / chemistry, pharmacology Plants / chemistry Radiation-Protective Agents / chemistry, isolation & purification, pharmacology* Tea / chemistry Vegetables Whole-Body Irradiation |
| Chemical | |
Reg. No./Substance:
|
0/Antimutagenic Agents; 0/Antioxidants; 0/Flavonoids; 0/Mutagens; 0/Plant Extracts; 0/Radiation-Protective Agents; 0/Tea; 491-70-3/Luteolin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Natural antimutagenic agents.
Next Document: Plant activation and its role in environmental mutagenesis and antimutagenesis.