Document Detail

Radioprotective effect of inosine and its enhancement by magnesium and global hypoxia.
MedLine Citation:
PMID:  1811724     Owner:  NLM     Status:  MEDLINE    
The slight radioprotective action of inosine, when injected intraperitoneally to mice shortly before gamma-irradiation, can be enhanced by the administration of magnesium aspartate. This effect can be explained by the additivity of the vasodilatory actions of both agents. Inosine increases the radioprotective effectiveness of hypobaric hypoxia (10% O2), probably due to the additivity of the hypoxic effects in radiosensitive tissues. Acute hypoxic toxicity, however, is decreased by inosine administration. The cumulation of radioprotective effects of inosine and of its antihypoxic action in vitally important organs can have a favourable influence in hypoxic radiotherapy.
M Pospísil; J Netíková; I Pipalová; K Volenec
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physiological research / Academia Scientiarum Bohemoslovaca     Volume:  40     ISSN:  0862-8408     ISO Abbreviation:  Physiol Res     Publication Date:  1991  
Date Detail:
Created Date:  1992-06-10     Completed Date:  1992-06-10     Revised Date:  2008-04-02    
Medline Journal Info:
Nlm Unique ID:  9112413     Medline TA:  Physiol Res     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  445-52     Citation Subset:  IM    
Institute of Biophysics, Czechoslovak Academy of Sciences, Brno.
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MeSH Terms
Blood Pressure / drug effects
Body Temperature / drug effects
Gamma Rays
Heart Rate / drug effects
Inosine / pharmacology*
Magnesium / pharmacology*
Mice, Inbred C57BL
Mice, Inbred CBA
Oxygen / metabolism*
Radiation-Protective Agents / pharmacology*
Reg. No./Substance:
0/Radiation-Protective Agents; 58-63-9/Inosine; 7439-95-4/Magnesium; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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