| Radioprotective effect of inosine and its enhancement by magnesium and global hypoxia. | |
| | |
MedLine Citation:
|
PMID: 1811724 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The slight radioprotective action of inosine, when injected intraperitoneally to mice shortly before gamma-irradiation, can be enhanced by the administration of magnesium aspartate. This effect can be explained by the additivity of the vasodilatory actions of both agents. Inosine increases the radioprotective effectiveness of hypobaric hypoxia (10% O2), probably due to the additivity of the hypoxic effects in radiosensitive tissues. Acute hypoxic toxicity, however, is decreased by inosine administration. The cumulation of radioprotective effects of inosine and of its antihypoxic action in vitally important organs can have a favourable influence in hypoxic radiotherapy. |
| | |
Authors:
|
M Pospísil; J Netíková; I Pipalová; K Volenec |
Related Documents
:
|
17358844 - Observation of b-->eta'k* and evidence for b+-->eta'rho+. 2559444 - Use of low-angle diamond knives leads to improved ultrastructural preservation of ultra... 18580944 - The borealis basin and the origin of the martian crustal dichotomy. 20464484 - Electron spin resonance (esr) detection of irradiated fish containing bone (gilthead se... 18338724 - Isolation of e. coli o157:h7 from milk and cattle faeces from urban dairy farming and n... 1917114 - Ige-positive duodenal mast cells in patients with food-related diarrhea. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Physiological research / Academia Scientiarum Bohemoslovaca Volume: 40 ISSN: 0862-8408 ISO Abbreviation: Physiol Res Publication Date: 1991 |
Date Detail:
|
Created Date: 1992-06-10 Completed Date: 1992-06-10 Revised Date: 2008-04-02 |
Medline Journal Info:
|
Nlm Unique ID: 9112413 Medline TA: Physiol Res Country: CZECHOSLOVAKIA |
Other Details:
|
Languages: eng Pagination: 445-52 Citation Subset: IM |
Affiliation:
|
Institute of Biophysics, Czechoslovak Academy of Sciences, Brno. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Pressure / drug effects Body Temperature / drug effects Gamma Rays Heart Rate / drug effects Inosine / pharmacology* Magnesium / pharmacology* Male Mice Mice, Inbred C57BL Mice, Inbred CBA Oxygen / metabolism* Radiation-Protective Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Radiation-Protective Agents; 58-63-9/Inosine; 7439-95-4/Magnesium; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Antiulcerogenic effect of pentacaine, chlorpromazine and stobadine on ethanol- and indomethacin-indu...
Next Document: Regenerative ability of hepatocytes is inhibited in early stages of liver fibrosis.