Document Detail


Radioprotection of the rat small intestine with topical WR-2721.
MedLine Citation:
PMID:  7922989     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The classic radioprotectant WR-2721 has been shown to reduce the severity of small bowel injury when administered systemically shortly before irradiation is delivered. This study tested the possibility that WR-2721 could provide protection when applied topically to intestinal mucosa. The second question addressed was the influence of pH on the effectiveness of this agent. METHODS: The model used involved irradiation of exteriorized rat small bowel. A length of intestine was compartmentalized. The various individual segments were filled with a lumenal Tris buffer (pH 9), WR-2721, or a combination of these two, then irradiated with 1100 cGy. The animals were sacrificed 5 days later. Surviving crypt cells and mucosal height were the criteria used to quantitate mucosal injury. RESULTS: The pH 9 buffer alone provided a small (16%) but significant preservation of crypt cell numbers. WR-2721 improved crypt survival by 54% at neutral pH, 83% at pH 9. CONCLUSIONS: These data indicate that WR-2721, when applied topically to the small bowel mucosa of the rat before irradiation, provides substantial protection against radiation damage. The degree of benefit is amplified greatly when the drug is in an alkaline medium.
Authors:
J P Delaney; M E Bonsack; I Felemovicius
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer     Volume:  74     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1994-10-27     Completed Date:  1994-10-27     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2379-84     Citation Subset:  AIM; IM    
Affiliation:
Department of Surgery, University of Minnesota Medical School, Minneapolis.
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Amifostine / administration & dosage,  pharmacology*
Animals
Female
Hydrogen-Ion Concentration
Intestinal Mucosa / drug effects,  radiation effects*
Intestine, Small / drug effects,  radiation effects*
Radiation Injuries / prevention & control*
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
20537-88-6/Amifostine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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