| Radioprotection of mouse colony forming units-spleen against heavy-charged particle damage by WR 2721. | |
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MedLine Citation:
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PMID: 3027738 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effectiveness of S-2-(3-aminopropylamino)ethylphosphorothioic acid (WR 2721) to protect against the heavy-charged particle beams with dose-averaged LET infinity's ranging from 26 to 260 keV/micron was studied using the marrow colony forming units-spleen as a model system. WR 2721 (400 mg/kg) was injected ip 30 min before whole-body irradiation in the plateau ionization region of the Bragg curve. Significant protection was observed at 26, 51, and 135 keV/micron LET values where the data were collected with 20Ne, 28Si, and 40Ar ions, respectively. The largest component of protection was the slope change, where at LET values of 26 and 51 keV/micron the DMFs (slope) were 2.1 and 2.3, respectively, which are very close to the gamma-ray value of 2.4 (gamma LET approximately equal to 0.2 keV/micron). Protection, however, decreased with increase in LET from 51 to 135 keV/micron to the DMF value of 1.2 and no significant protection was observed against 56Fe ions at 260 keV/micron. Significant increases in extrapolation number occurred with gamma rays and neon particles. The results are discussed in terms of charged particle track structure, radiation chemistry, and potential clinical applications. |
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Authors:
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S M Afzal; E J Ainsworth |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Radiation research Volume: 109 ISSN: 0033-7587 ISO Abbreviation: Radiat. Res. Publication Date: 1987 Jan |
Date Detail:
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Created Date: 1987-03-17 Completed Date: 1987-03-17 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0401245 Medline TA: Radiat Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 118-26 Citation Subset: IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amifostine
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pharmacology* Animals Argon Bone Marrow / radiation effects* Bone Marrow Cells Colony-Forming Units Assay Dose-Response Relationship, Radiation Energy Transfer* Gamma Rays Hematopoietic Stem Cells / radiation effects Iron Mice Neon Organothiophosphorus Compounds / pharmacology* Radiation, Ionizing Silicon Spleen / cytology, radiation effects* |
| Grant Support | |
ID/Acronym/Agency:
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1F06TW00980-01/TW/FIC NIH HHS; CA15184/CA/NCI NIH HHS; CA17411/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Organothiophosphorus Compounds; 20537-88-6/Amifostine; 7439-89-6/Iron; 7440-01-9/Neon; 7440-21-3/Silicon; 7440-37-1/Argon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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