Document Detail


Radioprotection of mouse colony forming units-spleen against heavy-charged particle damage by WR 2721.
MedLine Citation:
PMID:  3027738     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effectiveness of S-2-(3-aminopropylamino)ethylphosphorothioic acid (WR 2721) to protect against the heavy-charged particle beams with dose-averaged LET infinity's ranging from 26 to 260 keV/micron was studied using the marrow colony forming units-spleen as a model system. WR 2721 (400 mg/kg) was injected ip 30 min before whole-body irradiation in the plateau ionization region of the Bragg curve. Significant protection was observed at 26, 51, and 135 keV/micron LET values where the data were collected with 20Ne, 28Si, and 40Ar ions, respectively. The largest component of protection was the slope change, where at LET values of 26 and 51 keV/micron the DMFs (slope) were 2.1 and 2.3, respectively, which are very close to the gamma-ray value of 2.4 (gamma LET approximately equal to 0.2 keV/micron). Protection, however, decreased with increase in LET from 51 to 135 keV/micron to the DMF value of 1.2 and no significant protection was observed against 56Fe ions at 260 keV/micron. Significant increases in extrapolation number occurred with gamma rays and neon particles. The results are discussed in terms of charged particle track structure, radiation chemistry, and potential clinical applications.
Authors:
S M Afzal; E J Ainsworth
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Radiation research     Volume:  109     ISSN:  0033-7587     ISO Abbreviation:  Radiat. Res.     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-03-17     Completed Date:  1987-03-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0401245     Medline TA:  Radiat Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  118-26     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Amifostine / pharmacology*
Animals
Argon
Bone Marrow / radiation effects*
Bone Marrow Cells
Colony-Forming Units Assay
Dose-Response Relationship, Radiation
Energy Transfer*
Gamma Rays
Hematopoietic Stem Cells / radiation effects
Iron
Mice
Neon
Organothiophosphorus Compounds / pharmacology*
Radiation, Ionizing
Silicon
Spleen / cytology,  radiation effects*
Grant Support
ID/Acronym/Agency:
1F06TW00980-01/TW/FIC NIH HHS; CA15184/CA/NCI NIH HHS; CA17411/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Organothiophosphorus Compounds; 20537-88-6/Amifostine; 7439-89-6/Iron; 7440-01-9/Neon; 7440-21-3/Silicon; 7440-37-1/Argon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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