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Radiopacity of intracerebral hemorrhage correlates with perihemorrhagic edema.
MedLine Citation:
PMID:  21951394     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background:  Experimental evidence indicates that iron plays a key role in edema formation after intracerebral hemorrhage (ICH). We investigated the relationship between ICH radiopacity on CT as a marker of hematoma iron content and perihemorrhagic edema (PHE) after ICH. Methods:  We retrospectively investigated patients with spontaneous lobar and ganglionic supratentorial ICH who received follow-up CT scans during the first 7 days after symptom onset (d1, d2-4, d5-7). Measurements of ICH and edema volumes were taken using a semiautomatic threshold-based volumetric algorithm. Radiopacity of the blood clot was determined using the mean Hounsfield unit (HU) count of the ICH. Results:  A total of 117 patients aged 71.92 ± 11.55 years with spontaneous ICH (34.63 ± 32.44 ml) were included in the analysis. Mean ICH radiopacity was 59.7 ± 3.4 HU. We found significantly larger relative PHE at d2-4 (1.7 ± 0.9 vs. 1.3 ± 0.8; P = 0.032) and d5-7 (2.0 ± 1.3 vs. 1.3 ± 0.9; P = 0.007) and larger peak relative PHE (2.3 ± 1.6 vs. 1.6 ± 1.1; P = 0.006) in patients with ICH radiopacity >60 HU (n = 59), as compared to patients with ICH radiopacity <60 HU (n = 58). Conclusions:  Higher ICH radiopacity, reflecting higher in vivo hematoma iron content, is associated with more PHE after ICH.
Authors:
I Wagner; B Volbers; M J Hilz; S Schwab; A Doerfler; D Staykov
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-26
Journal Detail:
Title:  European journal of neurology : the official journal of the European Federation of Neurological Societies     Volume:  -     ISSN:  1468-1331     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9506311     Medline TA:  Eur J Neurol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Author(s). European Journal of Neurology © 2011 EFNS.
Affiliation:
Department of Neurology, University of Erlangen-Nuremberg, Erlangen, Germany Departments of Neurology, Medicine and Psychiatry, School of Medicine, New York University, New York, NY, USA Department of Neuroradiology, University of Erlangen-Nuremberg, Erlangen, Germany.
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