Document Detail

Radionuclide imaging in ischaemic heart failure.
MedLine Citation:
PMID:  19710085     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION OR BACKGROUND: Many tests are available for the investigation of patients with heart failure. The identification of the underlying aetiology of ventricular dysfunction is crucial as early treatment may limit or even reverse myocardial abnormalities.
SOURCES OF DATA: This article describes cardiac radionuclide imaging techniques and their applications in ischaemic ventricular dysfunction. Evidence for the role of these techniques is summarized with particular reference to current guidelines.
AREAS OF AGREEMENT: Both positron emission tomography (PET) and single photon emission computed tomography (SPECT) techniques are widely validated for the detection of myocardial viability and their use is recommended in both national and international guidelines.
AREAS OF CONTROVERSY: Although assessments of ventricular phase and myocardial innervation hold promise for the stratification of patients to cardiac resynchronization therapy, the poor performance of echocardiographic predictors of response in the recently published PROSPECT trial suggest that these techniques face a tough challenge.
GROWING POINTS: The use of integrated multimodality imaging techniques such as PET/computed tomography to assess for ischaemic causes of left ventricular dysfunction is an area that is currently under investigation, as is the role of nuclear techniques in the assessment of stem cell retention, distribution and function when used in patients with heart failure.
AREAS TIMELY FOR DEVELOPING RESEARCH: Ongoing developments in radionuclide molecular imaging for assessment of angiogenesis, apoptosis and interstitial alterations during cardiac remodeling may have important implications for the prognosis and treatment of patients with heart failure.
James Stirrup; Annelies Maenhout; Kshama Wechalekar; Constantinos Anagnostopoulos
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  British medical bulletin     Volume:  92     ISSN:  1471-8391     ISO Abbreviation:  Br. Med. Bull.     Publication Date:  2009  
Date Detail:
Created Date:  2009-12-16     Completed Date:  2010-04-09     Revised Date:  2012-09-10    
Medline Journal Info:
Nlm Unique ID:  0376542     Medline TA:  Br Med Bull     Country:  England    
Other Details:
Languages:  eng     Pagination:  43-59     Citation Subset:  IM    
Department of Nuclear Medicine, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Saint Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK.
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MeSH Terms
Cardiac Pacing, Artificial
Heart Failure / physiopathology,  radionuclide imaging*,  therapy
Myocardial Ischemia / radionuclide imaging*
Positron-Emission Tomography / methods
Radiopharmaceuticals / diagnostic use*
Tomography, Emission-Computed, Single-Photon / methods
Ventricular Dysfunction, Left / physiopathology,  radionuclide imaging
Reg. No./Substance:

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