| Radionuclide imaging in ischaemic heart failure. | |
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MedLine Citation:
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PMID: 19710085 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION OR BACKGROUND: Many tests are available for the investigation of patients with heart failure. The identification of the underlying aetiology of ventricular dysfunction is crucial as early treatment may limit or even reverse myocardial abnormalities. SOURCES OF DATA: This article describes cardiac radionuclide imaging techniques and their applications in ischaemic ventricular dysfunction. Evidence for the role of these techniques is summarized with particular reference to current guidelines. AREAS OF AGREEMENT: Both positron emission tomography (PET) and single photon emission computed tomography (SPECT) techniques are widely validated for the detection of myocardial viability and their use is recommended in both national and international guidelines. AREAS OF CONTROVERSY: Although assessments of ventricular phase and myocardial innervation hold promise for the stratification of patients to cardiac resynchronization therapy, the poor performance of echocardiographic predictors of response in the recently published PROSPECT trial suggest that these techniques face a tough challenge. GROWING POINTS: The use of integrated multimodality imaging techniques such as PET/computed tomography to assess for ischaemic causes of left ventricular dysfunction is an area that is currently under investigation, as is the role of nuclear techniques in the assessment of stem cell retention, distribution and function when used in patients with heart failure. AREAS TIMELY FOR DEVELOPING RESEARCH: Ongoing developments in radionuclide molecular imaging for assessment of angiogenesis, apoptosis and interstitial alterations during cardiac remodeling may have important implications for the prognosis and treatment of patients with heart failure. |
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Authors:
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James Stirrup; Annelies Maenhout; Kshama Wechalekar; Constantinos Anagnostopoulos |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: British medical bulletin Volume: 92 ISSN: 1471-8391 ISO Abbreviation: Br. Med. Bull. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-12-16 Completed Date: 2010-04-09 Revised Date: 2012-09-10 |
Medline Journal Info:
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Nlm Unique ID: 0376542 Medline TA: Br Med Bull Country: England |
Other Details:
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Languages: eng Pagination: 43-59 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Saint Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cardiac Pacing, Artificial Heart Failure / physiopathology, radionuclide imaging*, therapy Humans Myocardial Ischemia / radionuclide imaging* Positron-Emission Tomography / methods Radiopharmaceuticals / diagnostic use* Tomography, Emission-Computed, Single-Photon / methods Ventricular Dysfunction, Left / physiopathology, radionuclide imaging |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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