Document Detail

Radionuclide assessment of regional differences in left ventricular wall motion and myocardial perfusion in idiopathic dilated cardiomyopathy.
MedLine Citation:
PMID:  8223729     Owner:  NLM     Status:  MEDLINE    
Regional variations in left ventricular contractility and myocardial perfusion are frequent in idiopathic dilated cardiomyopathy and might result from an increase in left ventricular wall stress responsible for regional wall motion abnormalities. The aim of the study was to perform radionuclide studies in patients with idiopathic dilated cardiomyopathy to assess regional left ventricular wall motion and myocardial perfusion abnormalities in this myocardial disease. We studied 29 men referred with idiopathic dilated cardiomyopathy and normal coronary angiograms. Rest radionuclide left ventriculography and exercise thallium-201 tomography were performed in all patients. The thallium-201 tomograms were divided into 20 segments for each patient. Mean left ventricular ejection fraction was 27 +/- 11%; 17 patients had diffuse hypokinesia (mean left ventricular ejection fraction: 24 +/- 9%) and 12 patients had predominant regional hypokinesia (mean left ventricular ejection fraction: 32 +/- 12%). Of all 580 tomographic segments, 186 had a reduction of thallium-201 uptake at exercise. Among them, reversibility was found in 53%. On the whole, 68% (158/232) of anterior, inferior and apical segments had a perfusion abnormality, compared with 8% (28/348) of septal and lateral segments (P < 0.0001). Left ventricular wall motion and myocardial perfusion abnormalities are heterogeneous and not evenly distributed in dilated cardiomyopathy. The alterations are predominant on the myocardial regions delineating the antero-posterior axis of the left ventricle. These findings suggest the possible role of increased left ventricular wall stress on this axis.
Y Juillière; P Y Marie; N Danchin; C Gillet; F Paille; G Karcher; A Bertrand; F Cherrier
Related Documents :
19351689 - Impact of infarct transmurality on layer-specific impairment of myocardial function: a ...
14571489 - Effect of recanalization of chronic total occlusions on global and regional left ventri...
21148449 - Myocardial lineage development.
18983659 - Cardiac involvement in patients with becker muscular dystrophy: new diagnostic and path...
15646409 - Comparison of myocardial gated single photon emission computerised tomography, planar r...
3873849 - Multiphasic cardiac magnetic resonance imaging: normal regional left ventricular wall t...
7095879 - The influence of hemodialysis fistulas on circulatory dynamics and left ventricular fun...
11356619 - Coronary and myocardial effects of acetaminophen: protection during ischemia-reperfusion.
12433889 - Antiarrhythmic and anti-ischaemic effects of angina in patients with and without corona...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European heart journal     Volume:  14     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1993-12-17     Completed Date:  1993-12-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1163-9     Citation Subset:  IM    
Department of Cardiology, CHU Nancy-Brabois, Vandoeuvre-les-Nancy, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cardiomyopathy, Dilated / physiopathology,  radionuclide imaging*,  ultrasonography
Exercise Test
Myocardial Contraction*
Thallium Radioisotopes / diagnostic use
Ventricular Function, Left*
Reg. No./Substance:
0/Thallium Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Trends in hospitalization for heart failure in Scotland 1980-1990.
Next Document:  Ischaemic threshold and haemodynamic changes during angina at rest in patients with unstable angina.