Document Detail

Radionuclide assessment of left ventricular function during dobutamine infusion in patients with coronary artery disease: comparison with ergometer exercise.
MedLine Citation:
PMID:  2323118     Owner:  NLM     Status:  MEDLINE    
The effects of dobutamine on left ventricular function were assessed employing radionuclide ventriculography (RNV) in 7 normal subjects (Group 1) and 21 patients with coronary artery disease (Group 2). After routine bicycle ergometer exercise RNV, dobutamine infusion was started at 5 micrograms/kg/min and the dosage was increased by 5 micrograms/kg/min every 4 minutes to a total of 15 micrograms/kg/min. In Group 1, left ventricular ejection fraction (LVEF) increased by both ergometer exercise and dobutamine infusion. In Group 2, LVEF did not increase during exercise, but increased during dobutamine infusion without evidence of significant myocardial ischemia. Only 2 patients in Group 2 had new regional wall motion abnormality. Left ventricular end-diastolic volume (LVEDV) in Group 2 increased from 191 +/- 19 to 210 +/- 18 ml during ergometer exercise, but decreased from 193 +/- 18 to 153 +/- 19 ml during dobutamine infusion. Short-term low-dose infusion of dobutamine may be used in patients without evidence of significant myocardial ischemia, but probably cannot be substituted for exercise testing in patients with mild to moderate coronary artery disease.
T Konishi; T Koyama; T Aoki; T Yada; Y Futagami; T Nakano; M Yamamuro; K Watanabe
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical cardiology     Volume:  13     ISSN:  0160-9289     ISO Abbreviation:  Clin Cardiol     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-05-24     Completed Date:  1990-05-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  183-8     Citation Subset:  IM    
First Department of Internal Medicine, Mie University School of Medicine, Japan.
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MeSH Terms
Coronary Disease / diagnosis,  physiopathology,  radionuclide imaging*
Dobutamine / administration & dosage,  diagnostic use,  pharmacology*
Exercise Test
Heart Ventricles / drug effects*,  physiopathology,  radionuclide imaging
Infusions, Intravenous
Middle Aged
Prospective Studies
Radionuclide Ventriculography*
Reg. No./Substance:

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