Document Detail

Radionuclide (MUGA) studies of left ventricular functional abnormalities in asymptomatic patients with sickle cell anemia.
MedLine Citation:
PMID:  8714504     Owner:  NLM     Status:  MEDLINE    
Radionuclide ventriculography was performed on 10 normal subjects and 39 patients with sickle cell anemia (10 homozygous and 29 heterozygous sicklers) at rest and after exercise. Their left ventricular (LV) function was assessed in both these situations. The results were then compared within the subgroups. The reduction in ejection fraction (EF) response (47.5 +/- 7 at rest and 46.4 +/- 8 at exercise in homozygous patients, and 52.4 +/- 8 at rest and 54.3 +/- 8 at exercise in heterozygous patients) was significant in both the homozygous and the heterozygous groups but more so in the former group. The diastolic filling was also significantly impaired in the homozygous group (PER 2.64 +/- 0.74, PFR 2.13 +/- 0.42 and PFR/HR 0.014 +/- 0.001). The study statistically demonstrates, that LV filling patterns are altered in the sickle cell patients, even in the absence of clinical symptoms relating to LV dysfunction. This fact may prove to be a marker of sickle cell heart disease. Frequent and significant sickling is probably the cause of more pronounced LV functional abnormalities in homozygous sicklers.
S Pani; T K Pande; S Hiran; K A Vishwanathan; A Sood
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Indian heart journal     Volume:  47     ISSN:  0019-4832     ISO Abbreviation:  Indian Heart J     Publication Date:    1995 Sep-Oct
Date Detail:
Created Date:  1996-12-04     Completed Date:  1996-12-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374675     Medline TA:  Indian Heart J     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  489-92     Citation Subset:  IM    
Department of Internal Medicine, JLN Hospital & Research Centre, Bhilai.
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MeSH Terms
Anemia, Sickle Cell / complications,  physiopathology*,  radionuclide imaging
Radionuclide Ventriculography*
Retrospective Studies
Ventricular Dysfunction, Left / etiology,  physiopathology,  radionuclide imaging*

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