Document Detail


Radionecrosis of normal tissue: studies on mouse tails.
MedLine Citation:
PMID:  304849     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Studies on the radionecrosis of mouse tails demonstrate the following modifications to the dose necessary for necrosis in 50 per cent of tails (the ND50): (a) There is very little reduction in ND50 values for irradiated lengths of tail from 2 cm to almost the whole tail, but there is a sharp increase in dose for lengths less than 1.5 cm. (b) The ND50 is high for unanesthetized mice irradiated in air, due to tissue hypoxia. (c) The hypoxia can be reduced by varying amounts by applying heat to the tail, or by flowing oxygen over the tail surface, or by anesthetizing the animal. (d) The ingress of oxygen through the surface can be reduced by placing a clamp round the proximal tail. These features are discussed with reference to the state and possible position of the target cells, and to the use of this assay technique in comparative studies.
Authors:
J H Hendry
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of radiation biology and related studies in physics, chemistry, and medicine     Volume:  33     ISSN:  0020-7616     ISO Abbreviation:  Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med.     Publication Date:  1978 Jan 
Date Detail:
Created Date:  1978-04-17     Completed Date:  1978-04-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0374725     Medline TA:  Int J Radiat Biol Relat Stud Phys Chem Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  47-55     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anesthetics / pharmacology
Animals
Dose-Response Relationship, Radiation
Female
Mice
Necrosis
Oxygen
Pentobarbital / pharmacology
Radiation Injuries, Experimental*
Radiation Tolerance
Radiotherapy Dosage
Skin / radiation effects
Tail / radiation effects*
Temperature
X-Rays
Chemical
Reg. No./Substance:
0/Anesthetics; 76-74-4/Pentobarbital; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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