Document Detail

Radionecrosis of normal tissue: studies on mouse tails.
MedLine Citation:
PMID:  304849     Owner:  NLM     Status:  MEDLINE    
Studies on the radionecrosis of mouse tails demonstrate the following modifications to the dose necessary for necrosis in 50 per cent of tails (the ND50): (a) There is very little reduction in ND50 values for irradiated lengths of tail from 2 cm to almost the whole tail, but there is a sharp increase in dose for lengths less than 1.5 cm. (b) The ND50 is high for unanesthetized mice irradiated in air, due to tissue hypoxia. (c) The hypoxia can be reduced by varying amounts by applying heat to the tail, or by flowing oxygen over the tail surface, or by anesthetizing the animal. (d) The ingress of oxygen through the surface can be reduced by placing a clamp round the proximal tail. These features are discussed with reference to the state and possible position of the target cells, and to the use of this assay technique in comparative studies.
J H Hendry
Related Documents :
820399 - The continuous inhalation of oxygen-15 for assessing regional oxygen extraction in the ...
11421079 - Photochemical oxygen consumption, oxygen evolution and spectral changes during uva irra...
7600839 - Oxygen status of arterial and mixed venous blood.
15313479 - The diving paradox: new insights into the role of the dive response in air-breathing ve...
1248269 - Effect of oxygen in graded concentrations upon tracheal mucous velocity. a study in ane...
22503309 - The canadian transfusion surveillance system: what is it and how can the data be used?
8105969 - Effective peritoneal capillary blood flow and peritoneal transfer parameters.
15319199 - Effect of sepsis on skeletal muscle oxygen consumption and tissue oxygenation: interpre...
11244199 - Predictors of deteriorating cerebral infarct: role of inflammatory mechanisms. would it...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of radiation biology and related studies in physics, chemistry, and medicine     Volume:  33     ISSN:  0020-7616     ISO Abbreviation:  Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med.     Publication Date:  1978 Jan 
Date Detail:
Created Date:  1978-04-17     Completed Date:  1978-04-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0374725     Medline TA:  Int J Radiat Biol Relat Stud Phys Chem Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  47-55     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anesthetics / pharmacology
Dose-Response Relationship, Radiation
Pentobarbital / pharmacology
Radiation Injuries, Experimental*
Radiation Tolerance
Radiotherapy Dosage
Skin / radiation effects
Tail / radiation effects*
Reg. No./Substance:
0/Anesthetics; 76-74-4/Pentobarbital; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Implication of protein aromatic amino acids in concanavalin A-carbohydrate interactions. A radiolyti...
Next Document:  Lethality in mammalian cells due to hyperthermia under oxic and hypoxic conditions.