Document Detail


Radiomodification of glyoxalase I in the liver and spleen of mice: adaptive response and split-dose effect.
MedLine Citation:
PMID:  11216867     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Glyoxalase system, particularly glyoxalase I (Gly I) plays an important role in regulation of cell division and is considered to be a metabolic indicator of cell proliferation. The glyoxalase system is likely to have a close link with cellular radiosensitivity. Therefore, we have examined the effect of adaptive and split-dose of y-rays on the activity of Gly I in the liver and spleen of mice. For the adaptive response studies, mice pre-treated with a conditioning dose of 0.5 Gy were given a challenging dose of 4 Gy at varying time intervals. In the split-dose studies, a dose of 4 Gy was delivered into two equal fractions and spaced at different time intervals. The results show that pre-exposure to a conditioning dose or the fractionation of total dose decreased the specific activity of Gly I in the liver and spleen of mice. The decreased activity of Gly I was suggestive of protective action induced by the conditioning dose and fractionation of dose. The similar pattern of radiation response of Gly I probably supported the possibility of involvement of a common pathway in the radiation-induced adaptive and split-dose effect. From these observations a close link between the Gly I and the adaptive-response as well as the split-dose effect is speculated. Since, the glyoxalase system is vital for a variety of biological functions including cell division and repair, the present findings may have relevance in understanding the dose-fractionation as well as the biological defence induced by low doses of radiations.
Authors:
A B Tiku; R K Kale
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  216     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-02-16     Completed Date:  2001-05-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  79-83     Citation Subset:  IM    
Affiliation:
Free Radical Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dose-Response Relationship, Radiation
Gamma Rays
Lactoylglutathione Lyase / metabolism*
Liver / enzymology,  radiation effects*
Male
Mice
Models, Chemical
Spleen / enzymology,  radiation effects*
Time Factors
Chemical
Reg. No./Substance:
EC 4.4.1.5/Lactoylglutathione Lyase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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