Document Detail

Radiological sinonasal findings in adults with cystic fibrosis.
MedLine Citation:
PMID:  19490807     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Care of cystic fibrosis (CF) patients has extended the expected survival far into adulthood. The morphological changes of adult CF patients' paranasal sinuses have not been thoroughly addressed.
METHODS: A retrospective review was performed of computed tomography imaging of adult CF patients at an academic medical center. Developmental changes, bone sclerosis, mucoceles, and degree of inflammation (using a modified Lund-Mackay scoring system) were assessed.
RESULTS: Forty-five patients were included in the study. The majority of frontal and sphenoid sinuses were either aplastic or hypoplastic. Maxillary hypoplasia was less commonly seen. Seven patients had mucoceles. Sclerosis of the sinuses was a common finding, affecting 84.4% of patients. Inflammation of the sinuses was also common, with a median modified Lund-Mackay score of 15.0 (out of a median 20 possible).
CONCLUSION: Poor development of the sinuses seen in pediatric CF patients persists into adulthood. Inflammation of the sinuses is a common finding. Bone sclerosis, likely caused by chronic inflammation, affects a large majority of these patients.
Richard R Orlandi; Richard H Wiggins
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of rhinology & allergy     Volume:  23     ISSN:  1945-8924     ISO Abbreviation:  Am J Rhinol Allergy     Publication Date:    2009 May-Jun
Date Detail:
Created Date:  2009-06-03     Completed Date:  2009-07-30     Revised Date:  2011-11-10    
Medline Journal Info:
Nlm Unique ID:  101490775     Medline TA:  Am J Rhinol Allergy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  307-11     Citation Subset:  IM    
Division of Otolaryngology-Head and Neck Surgery, University of Utah, Salt Lake City, Utah 84132, USA.
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MeSH Terms
Cystic Fibrosis / pathology,  radiography*
Inflammation / radiography
Middle Aged
Paranasal Sinuses / radiography*
Retrospective Studies
Tomography, X-Ray Computed

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